Amanita phalloides poisoning: Mechanisms of toxicity and treatment

J Garcia, VM Costa, A Carvalho, P Baptista… - Food and chemical …, 2015 - Elsevier
Amanita phalloides, also known as 'death cap', is one of the most poisonous mushrooms,
being involved in the majority of human fatal cases of mushroom poisoning worldwide. This …

Amanitin intoxication: effects of therapies on clinical outcomes–a review of 40 years of reported cases

JL Tan, J Stam, AP van den Berg… - Clinical …, 2022 - Taylor & Francis
Background and aims Amanita phalloides poisoning causes severe liver damage which
may be potentially fatal. Several treatments are available, but their effectiveness has not …

Mechanism and treatment of α-amanitin poisoning

J Xue, X Lou, D Ning, R Shao, G Chen - Archives of toxicology, 2023 - Springer
Amanita poisoning has a high mortality rate. The α-amanitin toxin in Amanita is the main
lethal toxin. There is no specific detoxification drug for α-amanitin, and the clinical treatment …

Hepatoprotective effects of resveratrol on α-amanitin-induced liver toxicity in rats

A Gezer, H Ustundag, AS Mendil, G Bedir, L Duysak - Toxicon, 2024 - Elsevier
Objective The hepatoprotective effects of resveratrol against α-Amanitin (α-AMA)-induced
liver toxicity were investigated in an experimental rat model, focusing on oxidative stress …

Management of Amanita phalloides poisoning: A literature review and update

Y Ye, Z Liu - Journal of critical care, 2018 - Elsevier
Amanita phalloides poisoning with a high mortality is a serious health problem in the world.
The typical clinical manifestations are usually characterized by the absence of any …

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity

B Wang, AH Wan, Y Xu, RX Zhang, BC Zhao… - Nature …, 2023 - nature.com
The “death cap”, Amanita phalloides, is the world's most poisonous mushroom, responsible
for 90% of mushroom-related fatalities. The most fatal component of the death cap is α …

Mushroom toxins: chemistry and toxicology

X Yin, AA Yang, JM Gao - Journal of agricultural and food …, 2019 - ACS Publications
Mushroom consumption is a global tradition that is still gaining popularity. However, foraging
for wild mushrooms and accidental ingestion of toxic mushrooms can result in serious illness …

N-acetylcysteine as a treatment for amatoxin poisoning: a systematic review

J Liu, Y Chen, Y Gao, JH Walline, X Lu, S Yu… - Clinical …, 2020 - Taylor & Francis
Introduction: Amatoxin leads to the majority of deaths by mushroom poisoning around the
world. Amatoxin causes gastrointestinal disturbances and multiple organ dysfunction …

A Case Study: What Doses of Amanita phalloides and Amatoxins Are Lethal to Humans?

I Yilmaz, F Ermis, I Akata… - … & environmental medicine, 2015 - journals.sagepub.com
There are few data estimating the human lethal dose of amatoxins or of the toxin level
present in ingested raw poisonous mushrooms. Here, we present a patient who intentionally …

Autophagy promotes α-amanitin-induced apoptosis of hepa1-6 liver cells

X Gu, L Zhang, W Sun, K Liu, H Xu, P Wu… - Chemical research in …, 2022 - ACS Publications
It is estimated that 90% of deaths from food poisoning in China can be attributed to Amanita
poisoning, whose main toxin is α-amanitin. Studies showed that apoptosis plays a critical …