SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

Structure of SARS-CoV-2 membrane protein essential for virus assembly

Z Zhang, N Nomura, Y Muramoto, T Ekimoto… - Nature …, 2022 - nature.com
The coronavirus membrane protein (M) is the most abundant viral structural protein and
plays a central role in virus assembly and morphogenesis. However, the process of M …

Structure of SARS-CoV-2 M protein in lipid nanodiscs

KA Dolan, M Dutta, DM Kern, A Kotecha, GA Voth… - Elife, 2022 - elifesciences.org
SARS-CoV-2 encodes four structural proteins incorporated into virions, spike (S), envelope
(E), nucleocapsid (N), and membrane (M). M plays an essential role in viral assembly by …

[HTML][HTML] Omicron BA. 2 lineage spreads in clusters and is concentrated in Denmark

PA Desingu, K Nagarajan - Journal of medical virology, 2022 - ncbi.nlm.nih.gov
Dear Editor, The Omicron variant has recently become a dominant variant globally with four
lineages such as BA. 1, BA. 2, BA. 3, and B. 1.1. 529. But little is known about which parts of …

Discovering biological conflict systems through genome analysis: evolutionary principles and biochemical novelty

L Aravind, LM Iyer, AM Burroughs - Annual Review of …, 2022 - annualreviews.org
Biological replicators, from genes within a genome to whole organisms, are locked in
conflicts. Comparative genomics has revealed a staggering diversity of molecular …

Using Alphafold2 to predict the structure of the Gp5/M dimer of porcine respiratory and reproductive syndrome virus

M Veit, MR Gadalla, M Zhang - International Journal of Molecular …, 2022 - mdpi.com
Porcine reproductive and respiratory syndrome virus is a positive-stranded RNA virus of the
family Arteriviridae. The Gp5/M dimer, the major component of the viral envelope, is required …

Homology‐based classification of accessory proteins in coronavirus genomes uncovers extremely dynamic evolution of gene content

D Forni, R Cagliani, C Molteni, F Arrigoni… - Molecular …, 2022 - Wiley Online Library
Coronaviruses (CoVs) have complex genomes that encode a fixed array of structural and
nonstructural components, as well as a variety of accessory proteins that differ even among …

[HTML][HTML] An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2

SS Hassan, V Kodakandla, EM Redwan, K Lundstrom… - PeerJ, 2022 - peerj.com
An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2 [PeerJ] Related
research Download Share Twitter Facebook Email PEER-REVIEWED An issue of concern …

[HTML][HTML] Photoglobin, a distinct family of non-heme binding globins, defines a potential photosensor in prokaryotic signal transduction systems

T Schneider, Y Tan, H Li, JS Fisher, D Zhang - Computational and …, 2022 - Elsevier
Globins constitute an ancient superfamily of proteins, exhibiting enormous structural and
functional diversity, as demonstrated by many heme-binding families and two non-heme …