Metabolic magnetic resonance imaging (MRI) using hyperpolarized (HP) pyruvate is
becoming a non‐invasive technique for diagnosing, staging, and monitoring response to …

Abstract Structure determination lies at the heart of many biochemical research programs.
However, the “giants”: X‐ray diffraction, electron microscopy, molecular dynamics …

Nuclear spin hyperpolarization enables real-time observation of metabolism and
intermolecular interactions in vivo. 1-13C-pyruvate is the leading hyperpolarized tracer …

Hyperpolarized (ie, polarized far beyond the thermal equilibrium) nuclear spins can result in
the radiofrequency amplification by stimulated emission of radiation (RASER) effect. Here …

Nuclear spin hyperpolarization is a quantum effect that enhances the nuclear magnetic
resonance signal by several orders of magnitude and has enabled real-time metabolic …

Magnetic resonance imaging of 13C-labeled metabolites enhanced by parahydrogen-
induced polarization (PHIP) enables real-time monitoring of processes within the body. We …

Observing pyruvate metabolism in vivo has become a focal point of molecular magnetic
resonance imaging. Signal amplification by reversible exchange (SABRE) has recently …

Hyperpolarization has become a powerful tool to enhance the sensitivity of magnetic
resonance. A universal tool to hyperpolarize small molecules in solution, however, has not …

Nuclear magnetic resonance has experienced great advances in developing and translating
hyperpolarization methods into procedures for fundamental and clinical studies. Here, we …

Hyperpolarized 13C MRI visualizes real-time metabolic processes in vivo. In this study, we
achieved high 13C polarization in situ in the bore of an MRI system for precursor molecules …