In women, the non-growing population of follicles that comprise the ovarian reserve is
determined at birth and serves as the reservoir for future fertility. This reserve of dormant …

Cryopreservation of ovarian tissue to preserve the fertility of girls and young women at high
risk of sterility is now widely practiced. Pieces of cryopreserved ovarian cortex can be …

STUDY QUESTION Can complete oocyte development be achieved from human ovarian
tissue containing primordial/unilaminar follicles and grown in vitro in a multi-step culture to …

Premature ovarian failure and infertility are major side effects of chemotherapy treatments in
young cancer patients. A more thorough understanding of the mechanism behind …

BACKGROUND Advanced maternal age is associated with reduced fertility and adverse
pregnancy outcomes. This review details recent developments in our understanding of the …

The removal and cryostorage of ovarian cortical biopsies is now offered as a fertility
preservation option for young women. The only available option to restore fertility using this …

The α and β cells act in concert to maintain blood glucose. The α cells release glucagon in
response to low levels of glucose to stimulate glycogenolysis in the liver. In contrast, β cells …

It is well established that pubertal activation of the reproductive axis and maintenance of
fertility are critically dependent on the magnitude of body energy reserves and the metabolic …

STUDY QUESTION What are the effects of cyclophosphamide exposure on the human ovary
and can anti-Mullerian hormone (AMH) and rapamycin protect against these? SUMMARY …

Removal and storage of ovarian cortical tissue is currently offered to young female cancer
patients undergoing potentially sterilizing chemotherapy and/or radiotherapy. For patients at …