Mitochondrial diseases are an unusually genetically and phenotypically heterogeneous
group of disorders, which are extremely challenging to treat. Currently, apart from supportive …

The fat body is responsible for a variety of functions related to energy metabolism in
arthropods, by controlling the processes of de novo glucose production (gluconeogenesis) …

Mitochondrial transcription, translation, and respiration require interactions between genes
encoded in two distinct genomes, generating the potential for mutations in nuclear and …

Background Juvenile hormone (JH) has been demonstrated to control adult lifespan in a
number of non-model insects where surgical removal of the corpora allata eliminates the …

Mitochondria are key in the metabolism of aerobic organisms and in ageing progression and
age-related diseases. Mitochondria are essential for obtaining ATP from glucose and fatty …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are
neurodegenerative disorders characterized by declining motor and cognitive functions. Even …

Ageing is accompanied by the accumulation of damaged molecules in cells due to the injury
produced by external and internal stressors. Among them, reactive oxygen species …

Mitochondria are key regulators of cellular homeostasis, and mitochondrial dysfunction is
strongly linked to neurodegenerative diseases, including Alzheimer's and Parkinson's …

Gene expression changes during aging are partly conserved across species, and suggest
that oxidative stress, inflammation and proteotoxicity result from mitochondrial malfunction …

Parameters correlated with age and mortality in Drosophila melanogaster include
decreased negative geotaxis and centrophobism behaviors, decreased climbing and …