Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …

Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

The mammalian brain contains neurogenic niches that comprise neural stem cells and other
cell types. Neurogenic niches become less functional with age, but how they change during …

The function of somatic stem cells declines with age. Understanding the molecular
underpinnings of this decline is key to counteract age-related disease. Here, we report a …

All multicellular organisms undergo a decline in tissue and organ function as they age. An
attractive theory is that a loss in stem cell number and/or activity over time causes this …

A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

Major developments in the neural stem cell (NSC) field in recent years provide new insights
into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on …

Aging results in a decline in neural stem cells (NSCs), neurogenesis, and cognitive function,
and evidence is emerging to demonstrate disrupted adult neurogenesis in the hippocampus …

Human aging affects the entire organism, but aging of the brain must undoubtedly be
different from that of all other organs, as neurons are highly differentiated postmitotic cells …

The BAF (mammalian SWI/SNF) complexes are a family of multi‐subunit ATP‐dependent
chromatin remodelers that use ATP hydrolysis to alter chromatin structure. Distinct BAF …