Bladder cancer is a global health issue with sex differences in incidence and prognosis.
Bladder cancer has distinct molecular subtypes with multiple pathogenic pathways …

The cohesin complex has a range of crucial functions in the cell. Cohesin is essential for
mediating chromatid cohesion during mitosis, for repair of double‐strand DNA breaks, and …

The cohesin complex participates in the organization of 3D genome through generating and
maintaining DNA loops. Stromal antigen 2 (STAG2), a core subunit of the cohesin complex …

Cohesin organizes the genome through the formation of chromatin loops. NIPBL activates
cohesin's ATPase and is essential for loop extrusion, but its requirement for cohesin loading …

Molecular profiling studies have shown that 85% of canine urothelial carcinomas (UC)
harbor an activating BRAF V595E mutation, which is orthologous to the V600E variant found …

Highlights•Networks are a useful framework to study chromatin structure
datasets.•Chromatin networks can be used to visualize the 3D epigenome and integrate …

In eukaryotic cells, the genome is organized in the form of chromatin composed of DNA and
histones that organize and regulate gene expression. The dysregulation of chromatin …

Cohesin shapes the chromatin architecture, including enhancer-promoter interactions. Its
components, especially STAG2, but not its paralog STAG1, are frequently mutated in …

One bottleneck in understanding the principles of 3D chromatin structures is caused by the
paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its …

Bladder cancer is the fifth most common cancer in the United States. Most bladder cancers
are early-stage lesions confined to the mucosa or submucosa and are therefore classified as …