Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …

Many bacterial pathogens can permanently colonize their host and establish either chronic
or recurrent infections that the immune system and antimicrobial therapies fail to eradicate …

Pathogenic bacteria taken up into the macrophage phagosome are the target of many anti-
microbial mechanisms. Although mitochondria-derived antimicrobial effectors like reactive …

Staphylococcus aureus causes invasive infections and easily acquires antibiotic resistance.
Even antibiotic-susceptible S. aureus can survive antibiotic therapy and persist, requiring …

Persisters are a subpopulation of bacteria that are not killed by antibiotics even though they
lack genetic resistance. Here we provide evidence that persisters can manifest as small …

Recently, the drawbacks arising from the overuse of antibiotics have drawn growing public
attention. Among them, drug-resistance (DR) and even multidrug-resistance (MDR) pose …

One of the possible solutions for the current antibiotic resistance crisis may be found in
(often bacteriophage-derived) peptidoglycan hydrolases. The first clinical trials of these …

Persisters—a drug-tolerant sub-population in an isogenic bacterial culture—have been
featured throughout the last decade due to their important role in recurrent bacterial …

Staphylococcus aureus (Sau) plays an important role in human infections occurring in both
the community and hospital settings. Sau-related chronic and relapsing infections are mainly …

Staphylococcus aureus causes a broad spectrum of diseases in humans and animals. It is
frequently associated with inflammatory skin disorders such as atopic dermatitis, where it …