Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by
widespread intravascular activation of coagulation that can be caused by infectious insults …

The goal of this review is to briefly summarize the two primary pathways of hemostasis,
primary hemostasis and secondary hemostasis, as well as to summarize anticoagulant …

This phase 3 pivotal study evaluated the safety, efficacy, and pharmacokinetics of a
recombinant FVIII Fc fusion protein (rFVIIIFc) for prophylaxis, treatment of acute bleeding …

A normal hemostatic response to vascular injury requires both factor VIII (FVIII) and von
Willebrand factor (VWF). In plasma, VWF and FVIII normally circulate as a noncovalent …

Modern thrombophilia testing fails to identify any underlying prothrombotic tendency in a
significant number of patients presenting with objectively confirmed venous …

Arterial and venous thrombosis constitute a major source of morbidity and mortality
worldwide. Association between thrombotic complications and cardiovascular and other …

The vascular endothelium has several important functions, including hemostasis. The
homeostasis of hemostasis is based on a fine balance between procoagulant and …

Normal hemostasis requires von Willebrand factor (VWF) to support platelet adhesion and
aggregation at sites of vascular injury. VWF is a multimeric glycoprotein built from identical …

Background Factor VIII replacement products have improved the care of patients with
hemophilia A, but the short half-life of these products affects the patients' quality of life. The …

Current factor VIII (FVIII) products display a half-life (t1/2) of∼ 8-12 hours, requiring frequent
intravenous injections for prophylaxis and treatment of patients with hemophilia A. rFVIIIFc is …