Cholesterol homeostasis is critical for normal growth and development. In addition to being
a major membrane lipid, cholesterol has multiple biological functions. These roles include …

The largest pool of free cholesterol in mammals resides in myelin membranes. Myelin
facilitates rapid saltatory impulse propagation by electrical insulation of axons. This function …

Cholesterol is an essential component of higher eukaryotic membranes and plays a crucial
role in membrane organization, dynamics and function. The G-protein coupled receptors …

Abstract Smith–Lemli–Opitz syndrome (SLOS) is a common autosomal-recessive disorder
that results from mutations in the gene encoding the cholesterol biosynthetic enzyme 7 …

G protein‐coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across cell membranes and represent major targets in the development of …

The G-protein coupled receptors (GPCRs) are the largest class of molecules involved in
signal transduction across membranes, and represent major drug targets in all clinical …

G protein-coupled receptors (GPCRs) are the largest and a diverse family of proteins
involved in signal transduction across biological membranes. GPCRs mediate a wide range …

One of the paradigms in cancer pathogenesis is the requirement of a cell to undergo
transformation from respiration to aerobic glycolysis–the Warburg effect–to become …

Cholesterol is an essential component of eukaryotic membranes and plays a crucial role in
membrane organization, dynamics and function. The G-protein coupled receptors (GPCRs) …

The serotonin 1A receptor is an important member of the G protein-coupled receptor (GPCR)
family. It is involved in the generation and modulation of a variety of cognitive and behavioral …