The development of the nervous and vascular systems constitutes primary events in the
evolution of the animal kingdom; the former provides electrical stimuli and coordination …

New neurons and glial cells are generated in an extensive germinal niche adjacent to the
walls of the lateral ventricles in the adult brain. The primary progenitors (B1 cells) have …

Cancers are believed to arise from cancer stem cells (CSCs), but it is not known if these cells
remain dependent upon the niche microenvironments that regulate normal stem cells. We …

Vascular endothelial growth factor (VEGF, VEGFA) is critical for blood vessel growth in the
developing and adult nervous system of vertebrates. Several recent studies demonstrate …

Angiogenesis and neurogenesis are coupled processes. Using a coculture system, we
tested the hypothesis that cerebral endothelial cells activated by ischemia enhance neural …

Intensive research in the last decade shows that the prototypic angiogenic factor vascular
endothelial growth factor (VEGF) can have direct effects in neurons and modulate processes …

All classes of antidepressants increase hippocampal cell proliferation and neurogenesis,
which contributes, in part, to the behavioral actions of these treatments. Among …

Rationale The pharmacological actions of most antidepressants are ascribed to the
modulation of serotonergic and/or noradrenergic transmission in the brain. During …

Vascular endothelial growth factor (VEGF) is a hypoxia-induced angiogenic protein that
exhibits a broad range of neurotrophic and neuroprotective effects in the central nervous …

Vascular endothelial growth factor (VEGF) is a well-known cellular mitogen, and a vascular
growth factor and permeability regulator. It participates in physiological and pathological …