Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Purinergic signalling, ie ATP as an extracellular signalling molecule and cotransmitter in
both peripheral and central neurons, is involved in the physiology of neurotransmission and …

This review is focused on the pathophysiology and therapeutic potential of purinergic
signalling. A wide range of diseases are considered, including those of the central nervous …

Adenosine signals through four distinct G protein-coupled receptors that are located at
various synapses, cell types and brain areas. Through them, adenosine regulates …

Etiology of the Alzheimer's disease (AD) is not fully understood. Different pathological
processes are considered, such as amyloid deposition, tau protein phosphorylation …

Recently, we have shown that ketamine given prior to stress exposure protects against the
development of depressive-like behavior in mice. These data suggest that it may be possible …

Evidences show that purinergic signaling is involved in processes associated with health
and disease, including noncommunicable, neurological, and degenerative diseases. These …

Cancer is the world's major health issue, scavenging lives of millions throughout the world. A
number of anticancer drugs have figured prominently in the diagnosis and treatment of …

The purinergic signaling system, including P2 receptors, plays an important role in various
central nervous system (CNS) disorders. Over the last few decades, a substantial amount of …

Epilepsy, a condition characterized by spontaneous recurrent epileptic seizures, is among
the most prevalent neurological disorders. This disorder is estimated to affect approximately …