Hypervalent aryliodoumiums are intensively investigated as arylating agents. They are
excellent surrogates to aryl halides, and moreover they exhibit better reactivity, which allows …

The reproducibility of experiments has been a long standing impediment for further scientific
progress. Computational methods have been instrumental in drug discovery efforts owing to …

Reproducibility and reusability of the results of data-based modeling studies are essential.
Yet, there has been—so far—no broadly supported format for the specification of parameter …

Cell-free protein synthesis has been widely used as a “breadboard” for design of synthetic
genetic networks. However, due to a severe lack of modularity, forward engineering of …

Motivation This article presents libRoadRunner 2.0, an extensible, high-performance, cross-
platform, open-source software library for the simulation and analysis of models expressed …

It is widely acknowledged that the construction of large-scale dynamic models in systems
biology requires complex modelling problems to be broken up into more manageable …

Periodic gene expression dynamics are key to cell and organism physiology. Studies of
oscillatory expression have focused on networks with intuitive regulatory negative feedback …

CRISPR-Cas transcriptional circuits hold great promise as platforms for engineering
metabolic networks and information processing circuits. Historically, prokaryotic CRISPR …

Abstract BioUML (homepage: http://www. biouml. org, main public server: https://ict. biouml.
org) is a web-based integrated environment (platform) for systems biology and the analysis …

Highlights•Synthetic biology aims to apply engineering principles in biology.•Insufficient part
libraries, standards, and software are challenges to the field.•Working on the challenges will …