STD-NMR: application to transient interactions between biomolecules—a quantitative approach
Saturation transfer difference NMR (STD NMR) spectroscopy is one of the most powerful
NMR techniques for detection and characterization of transient (fast) receptor–ligand …
NMR techniques for detection and characterization of transient (fast) receptor–ligand …
Applications of saturation transfer difference NMR in biological systems
A Bhunia, S Bhattacharjya, S Chatterjee - Drug discovery today, 2012 - Elsevier
The method of saturation transfer difference (STD) nuclear magnetic resonance (NMR) is an
indispensable NMR tool in drug discovery. It identifies binding epitope (s) at the atomic …
indispensable NMR tool in drug discovery. It identifies binding epitope (s) at the atomic …
Ligand–receptor binding affinities from saturation transfer difference (STD) NMR spectroscopy: the binding isotherm of STD initial growth rates
J Angulo, PM Enríquez‐Navas… - Chemistry–A European …, 2010 - Wiley Online Library
The direct evaluation of dissociation constants (KD) from the variation of saturation transfer
difference (STD) NMR spectroscopy values with the receptor–ligand ratio is not feasible due …
difference (STD) NMR spectroscopy values with the receptor–ligand ratio is not feasible due …
The SARS‐CoV‐2 spike glycoprotein directly binds exogeneous sialic acids: A NMR view
L Unione, MJ Moure, MP Lenza, I Oyenarte… - Angewandte …, 2022 - Wiley Online Library
The interaction of the SARS CoV2 spike glycoprotein with two sialic acid‐containing
trisaccharides (α2, 3 and α2, 6 sialyl N‐acetyllactosamine) has been demonstrated by NMR …
trisaccharides (α2, 3 and α2, 6 sialyl N‐acetyllactosamine) has been demonstrated by NMR …
“Rules of engagement” of protein–glycoconjugate interactions: a molecular view achievable by using NMR spectroscopy and molecular modeling
Understanding the dynamics of protein–ligand interactions, which lie at the heart of host–
pathogen recognition, represents a crucial step to clarify the molecular determinants …
pathogen recognition, represents a crucial step to clarify the molecular determinants …
Analysis of the specific interactions between the lectin domain of malectin and diglucosides
T Schallus, K Fehér, U Sternberg, V Rybin… - …, 2010 - academic.oup.com
The endoplasmic reticulum malectin is a highly conserved protein in the animal kingdom
that has no counterpart so far in lower organisms. We recently determined the structure of its …
that has no counterpart so far in lower organisms. We recently determined the structure of its …
Use of NMR saturation transfer difference spectroscopy to study ligand binding to membrane proteins
RP Venkitakrishnan, O Benard, M Max… - … Protein Structure and …, 2012 - Springer
Detection of weak ligand binding to membrane-spanning proteins, such as receptor proteins
at low physiological concentrations, poses serious experimental challenges. Saturation …
at low physiological concentrations, poses serious experimental challenges. Saturation …
Practical aspects of NMR-based fragment screening
CA Lepre - Methods in Enzymology, 2011 - Elsevier
NMR spectroscopy is a popular and highly versatile screening method for fragment-based
drug discovery. NMR methods are capable of robustly detecting the binding of fragments to …
drug discovery. NMR methods are capable of robustly detecting the binding of fragments to …
NMR and molecular recognition. The application of ligand-based NMR methods to monitor molecular interactions
L Unione, S Galante, D Diaz, J Jiménez-Barbero - MedChemComm, 2014 - pubs.rsc.org
NMR spectroscopy allows the monitoring of molecular recognition processes in solution.
Nowadays, a plethora of NMR methods are available to deduce the key features of the …
Nowadays, a plethora of NMR methods are available to deduce the key features of the …
NMR screening and hit validation in fragment based drug discovery
R Campos-Olivas - Current Topics in Medicinal Chemistry, 2011 - ingentaconnect.com
Over the past three decades nuclear magnetic resonance spectroscopy has been
developed into a mature technique for the characterization of interactions of small molecule …
developed into a mature technique for the characterization of interactions of small molecule …