Manganese is essential for neuronal health
KJ Horning, SW Caito, KG Tipps… - Annual review of …, 2015 - annualreviews.org
The understanding of manganese (Mn) biology, in particular its cellular regulation and role
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …
[HTML][HTML] Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair
J Lafrance-Vanasse, GJ Williams, JA Tainer - Progress in biophysics and …, 2015 - Elsevier
Abstract The Mre11-Rad50-Nbs1 (MRN) complex is a dynamic macromolecular machine
that acts in the first steps of DNA double strand break repair, and each of its components has …
that acts in the first steps of DNA double strand break repair, and each of its components has …
The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once
SE Tsutakawa, J Lafrance-Vanasse, JA Tainer - DNA repair, 2014 - Elsevier
To avoid genome instability, DNA repair nucleases must precisely target the correct
damaged substrate before they are licensed to incise. Damage identification is a challenge …
damaged substrate before they are licensed to incise. Damage identification is a challenge …
A survey of reported disease-related mutations in the MRE11-RAD50-NBS1 complex
The MRE11-RAD50-NBS1 (MRN) protein complex is one of the primary vehicles for
repairing DNA double strand breaks and maintaining the genomic stability within the cell …
repairing DNA double strand breaks and maintaining the genomic stability within the cell …
Mechanism and significance of chromosome damage repair by homologous recombination
Homologous recombination (HR) is a major, conserved pathway of chromosome damage
repair. It not only fulfills key functions in the removal of deleterious lesions such as DNA …
repair. It not only fulfills key functions in the removal of deleterious lesions such as DNA …
DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA
Abstract The Mre11–Rad50–Nbs1 (MRN) complex plays important roles in sensing DNA
damage, as well as in resecting and tethering DNA ends, and thus participates in double …
damage, as well as in resecting and tethering DNA ends, and thus participates in double …
Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms
JA Regal, TA Festerling, JM Buis… - Human molecular …, 2013 - academic.oup.com
DNA double-strand breaks (DSBs) can lead to instability of the genome if not repaired
correctly. The MRE11/RAD50/NBS1 (MRN) complex binds DSBs and initiates damage …
correctly. The MRE11/RAD50/NBS1 (MRN) complex binds DSBs and initiates damage …
Cervical dystonia and no oculomotor apraxia as new manifestation of ataxia-telangiectasia-like disorder 1–case report and review of the literature
A Bajek, D Przewodowska, D Koziorowski… - Frontiers in …, 2023 - frontiersin.org
Ataxia-telangiectasia-like disorder 1 (ATLD1) is a rare neurodegenerative disorder
associated with early onset ataxia and oculomotor apraxia. The genetic determination of …
associated with early onset ataxia and oculomotor apraxia. The genetic determination of …
Structural studies of DNA end detection and resection in homologous recombination
CB Schiller, FU Seifert… - Cold Spring …, 2014 - cshperspectives.cshlp.org
DNA double-strand breaks are repaired by two major pathways, homologous recombination
or nonhomologous end joining. The commitment to one or the other pathway proceeds via …
or nonhomologous end joining. The commitment to one or the other pathway proceeds via …
Mre11-Rad50–dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1
The Mre11-Rad50-Nbs1 (MRN) protein complex and ATM/Tel1 kinase protect genome
integrity through their functions in DNA double-strand break (DSB) repair, checkpoint …
integrity through their functions in DNA double-strand break (DSB) repair, checkpoint …