Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography

ES Olson, W Dong, BE Applegate, KK Charaziak… - Hearing Research, 2024 - Elsevier
Beginning in 2006, optical coherence tomography (OCT) has been adapted for use as a
vibrometer for hearing research. The application of OCT in this field, particularly for studying …

Green porous benzamide-like nanomembranes for hazardous cations detection, separation, and concentration adjustment

N Rabiee, Y Fatahi, M Asadnia, H Daneshgar… - Journal of Hazardous …, 2022 - Elsevier
Green biomaterials play a crucial role in the diagnosis and treatment of diseases as well as
health-related problem-solving. Typically, biocompatibility, biodegradability, and mechanical …

[HTML][HTML] Dabrafenib protects from cisplatin-induced hearing loss in a clinically relevant mouse model

MA Ingersoll, RD Lutze, CK Pushpan, RG Kelmann… - JCI insight, 2023 - ncbi.nlm.nih.gov
The widely used chemotherapy cisplatin causes permanent hearing loss in 40%–60% of
patients with cancer. One drug, sodium thiosulfate, is approved by the FDA for use in …

Cochlear motion across the reticular lamina implies that it is not a stiff plate

NH Cho, S Puria - Scientific Reports, 2022 - nature.com
Within the cochlea, the basilar membrane (BM) is coupled to the reticular lamina (RL)
through three rows of piezo-like outer hair cells (OHCs) and supporting cells that endow …

Cochlear aging disrupts the correlation between spontaneous rate and sound-level coding in auditory nerve fibers

AN Heeringa, F Teske, G Ashida… - Journal of …, 2023 - journals.physiology.org
The spiking activity of auditory nerve fibers (ANFs) transmits information about the acoustic
environment from the cochlea to the central auditory system. Increasing age leads to …

Best frequencies and temporal delays are similar across the low-frequency regions of the guinea pig cochlea

G Burwood, P Hakizimana, AL Nuttall, A Fridberger - Science Advances, 2022 - science.org
The cochlea maps tones with different frequencies to distinct anatomical locations. For
instance, a faint 5000-hertz tone produces brisk responses at a place approximately 8 …

Deiters cells act as mechanical equalizers for outer hair cells

W Zhou, T Jabeen, S Sabha, J Becker… - Journal of …, 2022 - Soc Neuroscience
The outer hair cells in the mammalian cochlea are cellular actuators essential for sensitive
hearing. The geometry and stiffness of the structural scaffold surrounding the outer hair cells …

An outer hair cell-powered global hydromechanical mechanism for cochlear amplification

W He, G Burwood, A Fridberger, AL Nuttall, T Ren - Hearing research, 2022 - Elsevier
It is a common belief that the mammalian cochlea achieves its exquisite sensitivity,
frequency selectivity, and dynamic range through an outer hair cell-based active process, or …

The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea

W He, G Burwood, EV Porsov, A Fridberger… - Scientific Reports, 2022 - nature.com
The prevailing theory of cochlear function states that outer hair cells amplify sound-induced
vibration to improve hearing sensitivity and frequency specificity. Recent micromechanical …

Reconstruction of transverse-longitudinal vibrations in the organ of Corti complex via optical coherence tomography

BL Frost, CE Strimbu, ES Olson - The Journal of the Acoustical Society …, 2023 - pubs.aip.org
Optical coherence tomography (OCT) is a common modality for measuring vibrations within
the organ of Corti complex (OCC) in vivo. OCT's uniaxial nature leads to limitations that …