Cell therapy: types, regulation, and clinical benefits

AEH El-Kadiry, M Rafei, R Shammaa - Frontiers in Medicine, 2021 - frontiersin.org
Cell therapy practices date back to the 19th century and continue to expand on
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …

Trends in mechanobiology guided tissue engineering and tools to study cell-substrate interactions: a brief review

AK Rajendran, D Sankar, S Amirthalingam… - Biomaterials …, 2023 - Springer
Sensing the mechanical properties of the substrates or the matrix by the cells and the
tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels …

Advancing tissue decellularized hydrogels for engineering human organoids

BS Moura, MV Monteiro, LP Ferreira… - Advanced Functional …, 2022 - Wiley Online Library
The extracellular matrix plays a critical role in bioinstructing cellular self‐assembly and
spatial (re) configuration processes that culminate in human organoids in vitro generation …

Engineered cell culture microenvironments for mechanobiology studies of brain neural cells

L Castillo Ransanz, PFJ Van Altena… - … in bioengineering and …, 2022 - frontiersin.org
The biomechanical properties of the brain microenvironment, which is composed of different
neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain …

Revealing the clinical potential of high-resolution organoids

J Ko, S Hyung, S Cheong, Y Chung, NL Jeon - Advanced Drug Delivery …, 2024 - Elsevier
The symbiotic interplay of organoid technology and advanced imaging strategies yields
innovative breakthroughs in research and clinical applications. Organoids, intricate three …

Insights on three dimensional organoid studies for stem cell therapy in regenerative medicine

PE Mulaudzi, H Abrahamse, A Crous - Stem Cell Reviews and Reports, 2024 - Springer
Regenerative medicine has developed as a promising discipline that utilizes stem cells to
address limitations in traditional therapies, using innovative techniques to restore and repair …

[HTML][HTML] Everything you always wanted to know about organoid-based models (and never dared to ask)

I Hautefort, M Poletti, D Papp, T Korcsmaros - Cellular and Molecular …, 2022 - Elsevier
Homeostatic functions of a living tissue, such as the gastrointestinal tract, rely on highly
sophisticated and finely tuned cell-to-cell interactions. These crosstalks evolve and …

Biotechnological advances and applications of human pluripotent stem cell-derived heart models

P Muniyandi, C O'Hern, MA Popa… - … in Bioengineering and …, 2023 - frontiersin.org
In recent years, significant biotechnological advancements have been made in engineering
human cardiac tissues and organ-like models. This field of research is crucial for both basic …

[HTML][HTML] Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application

L Donati, ML Valicenti, S Giannoni… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Mechanosensing and mechanotransduction pathways between the Extracellular Matrix
(ECM) and cells form the essential crosstalk that regulates cell homeostasis, tissue …

Organoid models: assessing lung cell fate decisions and disease responses

DC Liberti, EE Morrisey - Trends in Molecular Medicine, 2021 - cell.com
Organoids can be derived from various cell types in the lung, and they provide a
reproducible and tractable model for understanding the complex signals driving cell fate …