Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …

Spinal muscular atrophy (SMA) is a devastating childhood motor neuron disease that, in the
most severe cases and when left untreated, leads to death within the first two years of life …

Abstract Alzheimer's Disease (AD), the most prevalent neurodegenerative disease of aging,
affects one in eight older Americans. Nearly all drug treatments tested for AD today have …

Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

Alzheimer's disease is characterized by the accumulation of amyloid plaques and
neurofibrillary tangles in the brain. However, emerging evidence suggests that …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in the
world. Motor impairment seen in PD is associated with dopaminergic neurotoxicity in the …

The aim of the present review is to discuss traditional hypotheses on the etiopathogenesis of
Alzheimer's disease (AD), as well as the role of metabolic-syndrome-related mechanisms in …

Asiatic acid (AA), a triterpenoid present in Centella asiatica, possesses the ability to cross
blood brain barrier and received considerable attention for its neuroprotective role. We have …

Abstract Cyclin-dependent kinase 5 (CDK5) is the serine/threonine-directed kinase mainly
found in the brain and plays a significant role in developing the central nervous system …

Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential to
modulate disease-associated proteins that have previously been considered undruggable …