Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
Z Zeng, M Fu, Y Hu, Y Wei, X Wei, M Luo - Molecular Cancer, 2023 - Springer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …
Targeted RNA editing: novel tools to study post-transcriptional regulation
RNA binding proteins (RBPs) regulate nearly all post-transcriptional processes within cells.
To fully understand RBP function, it is essential to identify their in vivo targets. Standard …
To fully understand RBP function, it is essential to identify their in vivo targets. Standard …
Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes
RNA-binding proteins (RBPs) are critical regulators of gene expression and RNA processing
that are required for gene function. Yet the dynamics of RBP regulation in single cells is …
that are required for gene function. Yet the dynamics of RBP regulation in single cells is …
[HTML][HTML] N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation
Summary N 6-Methyladenosine (m 6 A) on mRNAs mediates different biological processes
and its dysregulation contributes to tumorigenesis. How m 6 A dictates its diverse molecular …
and its dysregulation contributes to tumorigenesis. How m 6 A dictates its diverse molecular …
Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing
RNA-binding proteins (RBPs) regulate diverse cellular processes by dynamically interacting
with RNA targets. However, effective methods to capture both stable and transient …
with RNA targets. However, effective methods to capture both stable and transient …
SON is an essential m6A target for hematopoietic stem cell fate
Stem cells regulate their self-renewal and differentiation fate outcomes through both
symmetric and asymmetric divisions. m 6 A RNA methylation controls symmetric commitment …
symmetric and asymmetric divisions. m 6 A RNA methylation controls symmetric commitment …
Improving bulk RNA-seq classification by transferring gene signature from single cells in acute myeloid leukemia
The advances in single-cell RNA sequencing (scRNA-seq) technologies enable the
characterization of transcriptomic profiles at the cellular level and demonstrate great promise …
characterization of transcriptomic profiles at the cellular level and demonstrate great promise …
Transcriptome reprogramming through alternative splicing triggered by apigenin drives cell death in triple-negative breast cancer
M Sudhakaran, TG Navarrete, K Mejía-Guerra… - Cell Death & …, 2023 - nature.com
Triple-negative breast cancer (TNBC) is characterized by its aggressiveness and resistance
to cancer-specific transcriptome alterations. Alternative splicing (AS) is a major contributor to …
to cancer-specific transcriptome alterations. Alternative splicing (AS) is a major contributor to …
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells
Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic
stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are …
stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are …
Comparison of TRIBE and STAMP for identifying targets of RNA binding proteins in human and Drosophila cells
KC Abruzzi, C Ratner, M Rosbash - Rna, 2023 - rnajournal.cshlp.org
RNA binding proteins (RBPs) perform a myriad of functions and are implicated in numerous
neurological diseases. To identify the targets of RBPs in small numbers of cells, we …
neurological diseases. To identify the targets of RBPs in small numbers of cells, we …