Adiponectin action from head to toe

K Brochu-Gaudreau, C Rehfeldt, R Blouin, V Bordignon… - Endocrine, 2010 - Springer
Adiponectin, the most abundant protein secreted by white adipose tissue, is known for its
involvement in obesity-related disorders such as insulin resistance, type 2 diabetes mellitus …

Role of fatty acid uptake and fatty acid β-oxidation in mediating insulin resistance in heart and skeletal muscle

L Zhang, W Keung, V Samokhvalov, W Wang… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Fatty acids are a major fuel source used to sustain contractile function in heart and oxidative
skeletal muscle. To meet the energy demands of these muscles, the uptake and β-oxidation …

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

JM Moreno-Navarrete, F Ortega… - The journal of …, 2013 - academic.oup.com
Context: Recently irisin (encoded by Fndc5 gene) has been reported to stimulate browning
and uncoupling protein 1 expression in sc adipose tissue of mice. Objective: The objective of …

Adiponectin-resistance in obesity

A Engin - Obesity and lipotoxicity, 2017 - Springer
The decrease in adiponectin levels are negatively correlated with chronic subclinical
inflammation markers in obesity. The hypertrophic adipocytes cause obesity-linked insulin …

Adiponectin and cardiovascular disease

R Shibata, N Ouchi, T Murohara - Circulation Journal, 2009 - jstage.jst.go.jp
Obesity is strongly associated with metabolic and cardiovascular disorders. Adiponectin is
an adipose-derived plasma protein that is downregulated in subjects with obesity-related …

Regulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytes

C Tao, A Sifuentes, WL Holland - Best practice & research Clinical …, 2014 - Elsevier
Adiponectin has received considerable attention for its potential anti-diabetic actions. The
adipokine exerts control of glucose and lipid homeostasis via critical effects within the liver …

The multifunctionality of CD36 in diabetes mellitus and its complications—update in pathogenesis, treatment and monitoring

K Puchałowicz, ME Rać - Cells, 2020 - mdpi.com
CD36 is a multiligand receptor contributing to glucose and lipid metabolism, immune
response, inflammation, thrombosis, and fibrosis. A wide range of tissue expression includes …

Adipokines as regulators of muscle metabolism and insulin sensitivity

DJ Dyck - Applied Physiology, Nutrition, and Metabolism, 2009 - cdnsciencepub.com
Skeletal muscle is the largest tissue responsible for the insulin-stimulated disposal of
glucose. However, identifying the link between excess body fat and impaired insulin …

Examining the potential of developing and implementing use of adiponectin-targeted therapeutics for metabolic and cardiovascular diseases

Y Liu, V Vu, G Sweeney - Frontiers in endocrinology, 2019 - frontiersin.org
Cardiometabolic diseases encompass those affecting the heart and vasculature as well as
other metabolic problems, such as insulin resistance, diabetes, and non-alcoholic fatty liver …

Obesity and cancer progression: is there a role of fatty acid metabolism?

S Balaban, LS Lee, M Schreuder… - BioMed research …, 2015 - Wiley Online Library
Currently, there is renewed interest in elucidating the metabolic characteristics of cancer and
how these characteristics may be exploited as therapeutic targets. Much attention has …