Acyl-CoA: diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …

Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …

The treatment of tuberculosis is extremely long. One of the reasons why Mycobacterium
tuberculosis elimination from the organism takes so long is that in particular environmental …

Persistence has evolved as a potent survival strategy to overcome adverse environmental
conditions. This capability is common to almost all bacteria, including all human bacterial …

As major eukaryotic lipid storage organelles, lipid droplets (LDs) are metabolic hubs
coordinating energy flux and building block distribution. Infectious pathogens often promote …

Host-derived fatty acids are an important carbon source for pathogenic mycobacteria during
infection. How mycobacterial cells regulate the catabolism of fatty acids to serve the …

The Mycobacterium tuberculosis (Mtb) VapBC4 toxin–antitoxin system is essential for the
establishment of Mtb infection. Using a multitier, systems-level approach, we uncovered the …

While most bacterial species taken up by macrophages are degraded through processing of
the bacteria-containing vacuole through the endosomal-lysosomal degradation pathway …

Caseous necrosis is a hallmark of tuberculosis (TB) pathology and creates a niche for drug-
tolerant persisters within the host. Cavitary TB and high bacterial burden in caseum require …

Mycobacterium tuberculosis is protected from antibiotic therapy by a multi-layered
hydrophobic cell envelope. Major facilitator superfamily (MFS) transporter Rv1410 and the …