Detection of mismatched human leukocyte antigens by adaptive immune cells is considered
as the main cause of transplant rejection, leading to either T-cell mediated rejection or …

Abstract Antibody-mediated rejection (AMR), including chronic AMR (cAMR), causes~ 50%
of kidney allograft losses each year. Despite attempts to develop well-tolerated and effective …

Abstract The XVI-th Banff Meeting for Allograft Pathology was held at Banff, Alberta, Canada,
from 19th to 23rd September 2022, as a joint meeting with the Canadian Society of …

Rejection remains the main cause of premature graft loss after kidney transplantation,
despite the use of potent immunosuppression. This highlights the need to better understand …

We studied the clinical, histologic, and molecular features distinguishing DSA-negative from
DSA-positive molecularly defined antibody-mediated rejection (mABMR). We analyzed …

Background. Trifecta (ClinicalTrials. gov# NCT04239703) is a prospective trial defining
relationships between donor-derived cell-free DNA (dd-cfDNA), donor-specific antibody …

Introduction Antibody-mediated rejection (ABMR) is a leading cause of kidney allograft
failure. Its therapy continues to be challenge, and no treatment has been approved for the …

Background The heterogeneous clinical presentation of graft microvascular inflammation
poses a major challenge to successful kidney transplantation. The effect of microvascular …

The Banff Classification for Allograft Pathology includes the use of gene expression in the
diagnosis of antibody-mediated rejection (AMR) of kidney transplants, but a predictive set of …

Different types of kidney transplantations are performed worldwide, including biologically
diverse donor/recipient combinations, which entail distinct patient/graft outcomes. Thus …