Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

Dendritic spines are small protrusive structures on dendritic surfaces, and function as
postsynaptic compartments for excitatory synapses. Plasticity of spine structure is associated …

Local translation regulates the axonal proteome, playing an important role in neuronal
wiring and axon maintenance. How axonal mRNAs are localized to specific subcellular sites …

Cellular stress leads to reprogramming of mRNA translation and formation of stress granules
(SGs), membraneless organelles consisting of mRNA and RNA-binding proteins. Although …

Investigating human oligodendrogenesis and the interaction of oligodendrocytes with
neurons and astrocytes would accelerate our understanding of the mechanisms underlying …

Abstract Fluorescent RNAs (FRs), aptamers that bind and activate fluorescent dyes, have
been used to image abundant cellular RNA species. However, limitations such as low …

Biomolecular condensates organize biochemical processes at the subcellular level and can
provide spatiotemporal regulation within a cell. Among these, ribonucleoprotein (RNP) …

Regulation of mRNA translation, the process by which ribosomes decode mRNAs into
polypeptides, is used to tune cellular protein levels. Currently, methods for observing the …

In response to pathogenic threats, naive T cells rapidly transition from a quiescent to an
activated state, yet the underlying mechanisms are incompletely understood. Using a pulsed …

INTRODUCTION RNA sequencing and in situ hybridization have revealed the presence of
an unexpectedly high number of RNA species in neuronal dendrites and axons, and many …