FKBP ligands—where we are and where to go?
JM Kolos, AM Voll, M Bauder, F Hausch - Frontiers in pharmacology, 2018 - frontiersin.org
In recent years, many members of the FK506-binding protein (FKBP) family were
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …
FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention
FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its
members have fundamental roles in the regulation of signalling pathways involved in …
members have fundamental roles in the regulation of signalling pathways involved in …
SCINA: a semi-supervised subtyping algorithm of single cells and bulk samples
Advances in single-cell RNA sequencing (scRNA-Seq) have allowed for comprehensive
analyses of single cell data. However, current analyses of scRNA-Seq data usually start from …
analyses of single cell data. However, current analyses of scRNA-Seq data usually start from …
Dual enhancement in the radiosensitivity of prostate cancer through nanoparticles and chemotherapeutics
Background Radiotherapy (RT) is an essential component in the treatment regimens for
many cancer patients. However, the dose escalation required to improve curative results is …
many cancer patients. However, the dose escalation required to improve curative results is …
The quantification and regulation of microtubule dynamics in the mitotic spindle
JJ Vicente, L Wordeman - Current opinion in cell biology, 2019 - Elsevier
Microtubules play essential roles in cellular organization, cargo transport, and chromosome
segregation during cell division. During mitosis microtubules form a macromolecular …
segregation during cell division. During mitosis microtubules form a macromolecular …
[HTML][HTML] The eEF1 family of mammalian translation elongation factors
The eEF1 family of mammalian translation elongation factors is comprised of the two
variants of eEF1A (eEF1A1 and eEF1A2), and the eEF1B complex. The latter consists of …
variants of eEF1A (eEF1A1 and eEF1A2), and the eEF1B complex. The latter consists of …
Melatonin regulates breast cancer progression by the lnc010561/miR-30/FKBP3 Axis
P Liu, X Xie, A Yang, Y Kong, D Allen-Gipson… - … Therapy-Nucleic Acids, 2020 - cell.com
Melatonin has been recognized to slow breast cancer growth. The molecular mechanisms
may involve long non-coding RNAs (lncRNAs). However, little is known on how melatonin …
may involve long non-coding RNAs (lncRNAs). However, little is known on how melatonin …
The emerging importance of immunophilins in fibrosis development
Immunophilins are a family of proteins encompassing FK506-binding proteins (FKBPs) and
cyclophilins (Cyps). FKBPs and Cyps exert peptidyl-prolyl cis-trans isomerase (PPIase) …
cyclophilins (Cyps). FKBPs and Cyps exert peptidyl-prolyl cis-trans isomerase (PPIase) …
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem–Like Cells In Vivo
D Wang, W Li, R Zhao, L Chen, N Liu, Y Tian, H Zhao… - Cancer research, 2019 - AACR
FDA-approved HDAC inhibitors exhibit dose-limiting adverse effects; thus, we sought to
improve the therapeutic windows for this class of drugs. In this report, we describe a new …
improve the therapeutic windows for this class of drugs. In this report, we describe a new …
SCINA: Semi-Supervised Analysis of Single Cells in silico
Advances in single-cell RNA sequencing (scRNA-Seq) have allowed for comprehensive
analyses of single cell data. However, current analyses of scRNA-Seq data usually start from …
analyses of single cell data. However, current analyses of scRNA-Seq data usually start from …