[HTML][HTML] HER2 testing in gastric cancer: a practical approach

J Rüschoff, W Hanna, M Bilous, M Hofmann… - Modern Pathology, 2012 - Elsevier
Trastuzumab in combination with capecitabine or 5-fluorouracil and cisplatin is approved by
the European Medicines Agency for the treatment of patients with human epidermal growth …

[HTML][HTML] Cell-blocks and immunohistochemistry

VB Shidham, LJ Layfield - Cytojournal, 2021 - ncbi.nlm.nih.gov
The interpretation of results on immunostained cell-block sections has to be compared with
the cumulative published data derived predominantly from formalin-fixed paraffin-embedded …

[HTML][HTML] Does confirmatory tumor biopsy alter the management of breast cancer patients with distant metastases?

C Simmons, N Miller, W Geddie, D Gianfelice… - Annals of oncology, 2009 - Elsevier
Background Decisions about systemic treatment of women with metastatic breast cancer are
often based on estrogen receptor (ER), progesterone receptor (PgR), and Her2 status of the …

Comparison of semi-quantitative scoring and artificial intelligence aided digital image analysis of chromogenic immunohistochemistry

J Bencze, M Szarka, B Kóti, W Seo, TG Hortobágyi… - Biomolecules, 2021 - mdpi.com
Semi-quantitative scoring is a method that is widely used to estimate the quantity of proteins
on chromogen-labelled immunohistochemical (IHC) tissue sections. However, it suffers from …

Discordances in ER, PR and HER2 receptors between primary and recurrent/metastatic lesions and their impact on survival in breast cancer patients

YF Yang, YY Liao, M Yang, NF Peng, SR Xie, YF Xie - Medical Oncology, 2014 - Springer
The aim of this study was to evaluate the frequency and prognostic impact of changes in the
estrogen (ER), progesterone (PR) and human epidermal growth factor receptor 2 (HER2) …

Development of automated brightfield double In Situ hybridization (BDISH) application for HER2 g ene and chromosome 17 centromere (CEN 17) for breast carcinomas and an assay …

H Nitta, B Hauss-Wegrzyniak, M Lehrkamp… - Diagnostic …, 2008 - Springer
Background Human epidermal growth factor receptor 2 (HER2) fluorescence in situ
hybridization (FISH) is a quantitative assay for selecting breast cancer patients for …

Impact of the 2018 ASCO/CAP HER2 guidelines update for HER2 testing by FISH in breast cancer

B Xu, J Shen, W Guo, W Zhao, Y Zhuang… - Pathology-Research and …, 2019 - Elsevier
Abstract Recently, the American Society of Clinical Oncology/College of American
Pathologists (ASCO/CAP) updated the guidelines on HER2 testing for invasive breast …

Computer-aided techniques for chromogenic immunohistochemistry: status and directions

S Di Cataldo, E Ficarra, E Macii - Computers in biology and medicine, 2012 - Elsevier
Although immunohistochemistry (IHC) is a popular imaging technique, the quantitative
analysis of IHC images via computer-aided methods is an emerging field that is gaining …

[HTML][HTML] CellBlockistry: Chemistry and art of cell-block making–A detailed review of various historical options with recent advances

VB Shidham - Cytojournal, 2019 - ncbi.nlm.nih.gov
Cell-blocks are paraffin-embedded versions of cytology specimens comparable to the
formalin-fixed paraffin-embedded (FFPE) tissue from surgical pathology specimens. They …

The effect of prolonged fixation on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast cancer …

LC Tong, N Nelson, J Tsourigiannis… - The American journal …, 2011 - journals.lww.com
Expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal
growth factor receptor 2 (HER2) is important in predicting a response to targeted therapies in …