Dysconnectivity in schizophrenia: where are we now?
The disconnection hypothesis suggests that the core symptoms of schizophrenia (SZ) are
related to aberrant, or 'dys-', connectivity between distinct brain regions. A proliferation of …
related to aberrant, or 'dys-', connectivity between distinct brain regions. A proliferation of …
Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness
JW Buckholtz, A Meyer-Lindenberg - Neuron, 2012 - cell.com
The panoply of cognitive, affective, motivational, and social functions that underpin everyday
human experience requires precisely choreographed patterns of interaction between …
human experience requires precisely choreographed patterns of interaction between …
[HTML][HTML] Allosteric modulation of GPCRs: new insights and potential utility for treatment of schizophrenia and other CNS disorders
G-protein-coupled receptors (GPCRs) play critical roles in regulating brain function. Recent
advances have greatly expanded our understanding of these receptors as complex …
advances have greatly expanded our understanding of these receptors as complex …
[HTML][HTML] Adolescent neurobiological susceptibility to social context
RA Schriber, AE Guyer - Developmental cognitive neuroscience, 2016 - Elsevier
Adolescence has been characterized as a period of heightened sensitivity to social contexts.
However, adolescents vary in how their social contexts affect them. According to …
However, adolescents vary in how their social contexts affect them. According to …
Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis
Genetic variation in catechol-O-methyltransferase (COMT), encoding an enzyme critical for
prefrontal dopamine flux, has been studied extensively using both behavioral and …
prefrontal dopamine flux, has been studied extensively using both behavioral and …
[HTML][HTML] Test–retest reliability of evoked BOLD signals from a cognitive–emotive fMRI test battery
Even more than in cognitive research applications, moving fMRI to the clinic and the drug
development process requires the generation of stable and reliable signal changes. The …
development process requires the generation of stable and reliable signal changes. The …
Genetic variation in CACNA1C affects brain circuitries related to mental illness
Context TheCACNA1Cgene (α-1C subunit of the L-type voltage-gated calcium channel) has
been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of …
been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of …
Neurobehavioral evidence for changes in dopamine system activity during adolescence
Human adolescence has been characterized by increases in risk-taking, emotional lability,
and deficient patterns of behavioral regulation. These behaviors have often been attributed …
and deficient patterns of behavioral regulation. These behaviors have often been attributed …
Executive function, neural circuitry, and genetic mechanisms in schizophrenia
DP Eisenberg, KF Berman - Neuropsychopharmacology, 2010 - nature.com
After decades of research aimed at elucidating the pathophysiology and etiology of
schizophrenia, it has become increasingly apparent that it is an illness knowing few …
schizophrenia, it has become increasingly apparent that it is an illness knowing few …
Age-related decline in brain resources modulates genetic effects on cognitive functioning
Individual differences in cognitive performance increase from early to late adulthood, likely
reflecting influences of a multitude of factors. We hypothesize that losses in neurochemical …
reflecting influences of a multitude of factors. We hypothesize that losses in neurochemical …