[HTML][HTML] The basic immunology of asthma
H Hammad, BN Lambrecht - Cell, 2021 - cell.com
In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …
Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma
W Luo, J Hu, W Xu, J Dong - Frontiers in Immunology, 2022 - frontiersin.org
Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th)
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …
[HTML][HTML] Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
A Alam, E Levanduski, P Denz, HS Villavicencio… - Cancer cell, 2022 - cell.com
TH 2 cells and innate lymphoid cells 2 (ILC2) can stimulate tumor growth by secreting pro-
tumorigenic cytokines such as interleukin-4 (IL-4), IL-5, and IL-13. However, the …
tumorigenic cytokines such as interleukin-4 (IL-4), IL-5, and IL-13. However, the …
[HTML][HTML] Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
Chimeric antigen receptor (CAR) T cell therapy effectively treats human cancer, but the loss
of the antigen recognized by the CAR poses a major obstacle. We found that in vivo vaccine …
of the antigen recognized by the CAR poses a major obstacle. We found that in vivo vaccine …
[HTML][HTML] Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
While intestinal Th17 cells are critical for maintaining tissue homeostasis, recent studies
have implicated their roles in the development of extra-intestinal autoimmune diseases …
have implicated their roles in the development of extra-intestinal autoimmune diseases …
Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer
Acetate metabolism is an important metabolic pathway in many cancers and is controlled by
acetyl-CoA synthetase 2 (ACSS2), an enzyme that catalyzes the conversion of acetate to …
acetyl-CoA synthetase 2 (ACSS2), an enzyme that catalyzes the conversion of acetate to …
Classification of human chronic inflammatory skin disease based on single-cell immune profiling
Inflammatory conditions represent the largest class of chronic skin disease, but the
molecular dysregulation underlying many individual cases remains unclear. Single-cell RNA …
molecular dysregulation underlying many individual cases remains unclear. Single-cell RNA …
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes
Abstract CD4+ effector lymphocytes (Teff) are traditionally classified by the cytokines they
produce. To determine the states that Teff cells actually adopt in frontline tissues in vivo, we …
produce. To determine the states that Teff cells actually adopt in frontline tissues in vivo, we …
METTL3-dependent m6A modification programs T follicular helper cell differentiation
T follicular helper (TFH) cells are specialized effector CD4+ T cells critical to humoral
immunity. Whether post-transcriptional regulation has a function in TFH cells is unknown …
immunity. Whether post-transcriptional regulation has a function in TFH cells is unknown …
Mechanisms of allergen immunotherapy in allergic rhinitis
G Drazdauskaitė, JA Layhadi, MH Shamji - Current allergy and asthma …, 2021 - Springer
Abstract Purpose of Review Allergic rhinitis (AR) is a chronic inflammatory immunoglobulin
(Ig) E-mediated disease of the nasal mucosa that can be triggered by the inhalation of …
(Ig) E-mediated disease of the nasal mucosa that can be triggered by the inhalation of …