Calcium regulation of single ryanodine receptor channel gating analyzed using HMM/MCMC statistical methods
RA Rosales, M Fill, AL Escobar - The Journal of general physiology, 2004 - rupress.org
Type-II ryanodine receptor channels (RYRs) play a fundamental role in intracellular Ca2+
dynamics in heart. The processes of activation, inactivation, and regulation of these …
dynamics in heart. The processes of activation, inactivation, and regulation of these …
Trends in body mass index according to educational attainment for urban Australian adults between 1980 and 2007
E Gearon, K Backholer, C Stevenson… - International Journal of …, 2015 - nature.com
Background: We have previously demonstrated that between the years 1980 and 2000, the
mean body mass index (BMI) of the urban Australian population increased, with greater …
mean body mass index (BMI) of the urban Australian population increased, with greater …
Subconductance gating and voltage sensitivity of sarcoplasmic reticulum K+ channels: a modeling approach
A Matyjaszkiewicz, E Venturi, F O'Brien, T Iida… - Biophysical …, 2015 - cell.com
Sarcoplasmic reticulum (SR) K+ channels are voltage-regulated channels that are thought to
be actively gating when the membrane potential across the SR is close to zero as is …
be actively gating when the membrane potential across the SR is close to zero as is …
Minimally and vaguely informative priors to combat practical parameter non-identifiability of hidden Markov models exemplified by ion channel data
JL Münch, R Schmauder, F Paul, M Habeck - bioRxiv, 2024 - biorxiv.org
Hidden Markov Model (HMM) inference for time-series data from ion channels or other
biomolecules is challenging. We argue that inference on partially observed chemical …
biomolecules is challenging. We argue that inference on partially observed chemical …
The power of two-dimensional dwell-time analysis for model discrimination, temporal resolution, multichannel analysis and level detection
T Huth, I Schroeder, UP Hansen - The Journal of membrane biology, 2006 - Springer
Abstract Two-dimensional (2D) dwell-time analysis of time series of single-channel patch-
clamp current was improved by employing a Hinkley detector for jump detection, introducing …
clamp current was improved by employing a Hinkley detector for jump detection, introducing …
Allosteric control of gating mechanisms revisited: the large conductance Ca2+-activated K+ channel
RA Rosales, WA Varanda - Biophysical journal, 2009 - cell.com
Abstract Large-conductance Ca 2+-activated K+ channels (BK) play a fundamental role in
modulating membrane potential in many cell types. The gating of BK channels and its …
modulating membrane potential in many cell types. The gating of BK channels and its …