Objective: To evaluate previously reported associations of copy number variants (CNVs)
with schizophrenia and to identify additional associations, the authors analyzed CNVs in the …

We discuss the detection of local signals that occur at the same location in multiple one-
dimensional noisy sequences, with particular attention to relatively weak signals that may …

Changepoint detection methods are used in many areas of science and engineering, for
example, in the analysis of copy number variation data to detect abnormalities in copy …

Motivation: High-throughput techniques facilitate the simultaneous measurement of DNA
copy number at hundreds of thousands of sites on a genome. Older techniques allow …

We propose a flexible change-point model for inhomogeneous Poisson Processes, which
arise naturally from next-generation DNA sequencing, and derive score and generalized …

Abstract Let Y 1,…, Y n be a sequence whose underlying mean is a step function with an
unknown number of the steps and unknown change points. The detection of the change …

Objective The authors used a genome-wide association study (GWAS) of multiply affected
families to investigate the association of schizophrenia to common single-nucleotide …

Array-based comparative genomic hybridization (aCGH) enables the measurement of DNA
copy number across thousands of locations in a genome. The main goals of analyzing …

BackgroundA significant number of patients with schizophrenia fail to respond to
antipsychotic medication. Although several studies have investigated associated patient …

After a brief review of previous frequentist and Bayesian approaches to multiple change-
points, we describe a Bayesian model for multiple parameter changes in a multiparameter …