The gene ontology knowledgebase in 2023

SA Aleksander, J Balhoff, S Carbon, JM Cherry… - Genetics, 2023 - academic.oup.com
Abstract The Gene Ontology (GO) knowledgebase (http://geneontology. org) is a
comprehensive resource concerning the functions of genes and gene products (proteins …

Proteomic and interactomic insights into the molecular basis of cell functional diversity

I Bludau, R Aebersold - Nature Reviews Molecular Cell Biology, 2020 - nature.com
The ability of living systems to adapt to changing conditions originates from their capacity to
change their molecular constitution. This is achieved by multiple mechanisms that modulate …

[PDF][PDF] The gene ontology knowledgebase in 2023

D Ebert, M Feuermann, P Gaudet, NL Harris, DP Hill… - Genetics, 2023 - crick.figshare.com
Abstract The Gene Ontology (GO) knowledgebase (http://geneontology. org) is a
comprehensive resource concerning the functions of genes and gene products (proteins …

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

D Szklarczyk, AL Gable, KC Nastou, D Lyon… - Nucleic acids …, 2021 - academic.oup.com
Cellular life depends on a complex web of functional associations between biomolecules.
Among these associations, protein–protein interactions are particularly important due to their …

WikiPathways: connecting communities

M Martens, A Ammar, A Riutta… - Nucleic acids …, 2021 - academic.oup.com
Abstract WikiPathways (https://www. wikipathways. org) is a biological pathway database
known for its collaborative nature and open science approaches. With the core idea of the …

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

A Stukalov, V Girault, V Grass, O Karayel, V Bergant… - Nature, 2021 - nature.com
The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-
depth understanding of molecular functions of viral proteins and their interactions with the …

The IntAct database: efficient access to fine-grained molecular interaction data

N Del Toro, A Shrivastava, E Ragueneau… - Nucleic acids …, 2022 - academic.oup.com
The IntAct molecular interaction database (https://www. ebi. ac. uk/intact) is a curated
resource of molecular interactions, derived from the scientific literature and from direct data …

The gene ontology resource: 20 years and still GOing strong

Gene Ontology Consortium - Nucleic acids research, 2019 - academic.oup.com
Abstract The Gene Ontology resource (GO; http://geneontology. org) provides structured,
computable knowledge regarding the functions of genes and gene products. Founded in …

Cytoscape stringApp 2.0: analysis and visualization of heterogeneous biological networks

NT Doncheva, JH Morris, H Holze… - Journal of proteome …, 2022 - ACS Publications
Biological networks are often used to represent complex biological systems, which can
contain several types of entities. Analysis and visualization of such networks is supported by …

[HTML][HTML] An atlas of protein homo-oligomerization across domains of life

H Schweke, M Pacesa, T Levin, CA Goverde, P Kumar… - Cell, 2024 - cell.com
Protein structures are essential to understanding cellular processes in molecular detail.
While advances in artificial intelligence revealed the tertiary structure of proteins at scale …