The process of bone remodeling is the result of the regulated balance between bone cell
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …

Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to
overproduction of fibroblast growth factor 23 (FGF23), with profound effects on patient …

Few investigators think of bone as an endocrine gland, even after the discovery that
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …

Abstract Tumour-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a
rare paraneoplastic disorder caused by tumours that secrete fibroblast growth factor 23 …

Calcium (Ca2+) and phosphate (PO43−) homeostasis are coordinated by systemic and local
factors that regulate intestinal absorption, influx and efflux from bone, and kidney excretion …

Living organisms are capable of inducing the crystallization and deposition of a wide variety
of minerals, 1 but the vertebrates mainly utilize the calcium phosphates in constructing their …

Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …

FGF23 is a bone-derived hormone that regulates systemic phosphate homeostasis, vitamin
D metabolism and α-Klotho expression through a novel bone-kidney axis. FGF23 inhibits …

Introduction Osteocytes represent 95% of all bone cells. These cells are old osteoblasts that
occupy the lacunar space and are surrounded by the bone matrix. They possess …

Given the dramatic increase in skeletal size during growth, the need to preserve skeletal
mass during adulthood, and the large capacity of bone to store calcium and phosphate …