Neuroprotective effects of estrogen in CNS injuries: insights from animal models

N Raghava, BC Das, SK Ray - Neuroscience and neuroeconomics, 2017 - Taylor & Francis
Among the estrogens that are biosynthesized in the human body, 17β-estradiol (estradiol or
E2) is the most common and the best estrogen for neuroprotection in animal models of the …

Mechanism of neuroprotection against experimental spinal cord injury by riluzole or methylprednisolone

C Sámano, A Nistri - Neurochemical research, 2019 - Springer
Any spinal cord injury carries the potential for persistent disability affecting motor, sensory
and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of …

[HTML][HTML] Targeting mitochondrial oxidative stress: potential neuroprotective therapy for spinal cord injury

Z He, C Zhang, JX Liang, FF Zheng, XY Qi… - Journal of Integrative …, 2023 - imrpress.com
Spinal cord injury (SCI) is a serious central nervous system (CNS) injury disease related to
hypoxia-ischemia and inflammation. It is characterized by excessive reactive oxygen …

Microglia activation contributes to quinolinic acid-induced neuronal excitotoxicity through TNF-α

W Feng, Y Wang, ZQ Liu, X Zhang, R Han, YZ Miao… - Apoptosis, 2017 - Springer
It has been reported that activation of NF-κB is involved in excitotoxicity; however, it is not
fully understood how NF-κB contributes to excitotoxicity. The aim of this study is to …

[PDF][PDF] Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets

J Ban, C Samano, M Mladinić, I Munitić - Croatian medical journal, 2019 - hrcak.srce.hr
The nervous system was traditionally investigated by focusing primarily on neurons as main
functional units (“neurocentric” view)(1). Recently, this standpoint has changed, and glial …

The role of low level laser therapy on neuropathic pain relief and interleukin-6 expression following spinal cord injury: an experimental study

N Mojarad, A Janzadeh, M Yousefifard… - Journal of chemical …, 2018 - Elsevier
Abstract Introduction The effect of Low Level Laser Therapy (LLLT) as a non-invasive
treatment of spinal cord injury (SCI) is still under investigation. Therefore, the present study …

Emerging three-dimensional neuronal culture assays for neurotherapeutics drug discovery

RS Rathore, SR Ayyannan… - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction Development of in vitro models mimicking the physiology and pathophysiology
of the brain is essential and remains a major challenge for the discovery of …

Neurokinin 1 receptor antagonist along with dexamethasone reduces the inflammation in COVID-19 patients: a novel therapeutic approach

R Mehboob, FJ Ahmad, A Qayyum… - … in Life Sciences, 2023 - submission.als-journal.com
Background: Corona virus infection is a respiratory infection, compromising the normal
breathing in critical patients by damaging the lungs. The aim of this study was to evaluate …

A mechanistic overview of spinal cord injury, oxidative DNA damage repair and neuroprotective therapies

J Kaur, A Mojumdar - International Journal of Neuroscience, 2023 - Taylor & Francis
Despite substantial development in medical treatment strategies scientists are struggling to
find a cure against spinal cord injury (SCI) which causes long term disability and paralysis …

Neuroprotective effect of propofol against excitotoxic injury to locomotor networks of the rat spinal cord in vitro

J Kaur, J Flores Gutiérrez, A Nistri - European Journal of …, 2016 - Wiley Online Library
Although neuroprotection to contain the initial damage of spinal cord injury (SCI) is difficult,
multicentre studies show that early neurosurgery under general anaesthesia confers …