Regulated cell death (RCD) in cancer: key pathways and targeted therapies

F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Curcumin as an enhancer of therapeutic efficiency of chemotherapy drugs in breast cancer

R Farghadani, R Naidu - International Journal of Molecular Sciences, 2022 - mdpi.com
Female breast cancer is the world's most prevalent cancer in 2020. Chemotherapy still
remains a backbone in breast cancer therapy and is crucial in advanced and metastatic …

[HTML][HTML] The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy

E Pavitra, J Kancharla, VK Gupta, K Prasad… - Biomedicine & …, 2023 - Elsevier
Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied
female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated …

Involvement and targeted intervention of benzo (a) pyrene-regulated apoptosis related proteome modification and muti-drug resistance in hepatocellular carcinoma

Y Yang, M Jin, Y Meng, Y Dai, S Chen, Y Zhou… - Cell Death & …, 2023 - nature.com
During the development of hepatocellular carcinoma (HCC), the mutual adaptation and
interaction of HCC cells and the microenvironment play an important role. Benzo (a) pyrene …

Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling

P Kubatka, L Koklesova, A Mazurakova… - Cancer and Metastasis …, 2024 - Springer
Cancer cell plasticity plays a crucial role in tumor initiation, progression, and metastasis and
is implicated in the multiple cancer defense mechanisms associated with therapy resistance …

Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome

CK Vadivel, A Willerslev-Olsen, MRJ Namini, Z Zeng… - Blood, 2024 - ashpublications.org
Patients with Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma
(CTCL), are prone to Staphylococcus aureus infections and have a poor prognosis due to …

Innovative nanotheranostics: Smart nanoparticles based approach to overcome breast cancer stem cells mediated chemo‐and radioresistances

P Kola, PKB Nagesh, PK Roy, K Deepak… - Wiley …, 2023 - Wiley Online Library
The alarming increase in the number of breast cancer patients worldwide and the increasing
death rate indicate that the traditional and current medicines are insufficient to fight against …

Dysregulated signalling pathways driving anticancer drug resistance

N Bou Antoun, AM Chioni - International Journal of Molecular Sciences, 2023 - mdpi.com
One of the leading causes of death worldwide, in both men and women, is cancer. Despite
the significant development in therapeutic strategies, the inevitable emergence of drug …

[HTML][HTML] Promising applications of nanotechnology in inhibiting chemo-resistance in solid tumors by targeting epithelial-mesenchymal transition (EMT)

M Tangsiri, A Hheidari, M Liaghat, M Razlansari… - Biomedicine & …, 2024 - Elsevier
The resistance of cancer cells to chemotherapy, also known as chemo-resistance, poses a
significant obstacle to cancer treatment and can ultimately result in patient mortality …

Modulating multidrug resistance to drug-based antitumor therapies through NF-κB signaling pathway: mechanisms and perspectives

D Wu, S Tian, W Zhu - Expert Opinion on Therapeutic Targets, 2023 - Taylor & Francis
Introduction Despite the advances made in cancer treatment in the past decades,
therapeutic efficacy is still quite challenging, partially due to the emergence of multidrug …