Biliary Atresia is a devastating pediatric cholangiopathy affecting the bile ducts of the liver. In
this review, we describe recent progress in the understanding of liver development with a …

Notch signaling controls multiple aspects of embryonic development and adult homeostasis.
Alagille syndrome is usually caused by a single mutation in the jagged canonical Notch …

Abstract Background & Aims Alagille syndrome (ALGS) manifests with peripheral
intrahepatic bile duct (IHBD) paucity, which can spontaneously resolve. In a model for ALGS …

Rational: The complex vascular architecture and diverse immune cells of the liver are critical
for maintaining liver homeostasis. However, quantification of the network of liver vasculature …

Fibrosis contributes to tissue repair, but excessive fibrosis disrupts organ function. Alagille
syndrome (ALGS, caused by mutations in JAGGED1) results in liver disease and …

Earlier data on liver development demonstrated that morphogenesis of the bile duct, portal
mesenchyme and hepatic artery is interdependent, yet how this interdependency is …

Spontaneous bleeds are a leading cause of death in the pediatric JAG1‐related liver
disease Alagille syndrome (ALGS). We asked whether there are sex differences in bleeding …

As the largest internal organ of the human body, the liver has an extremely complex vascular
network and multiple types of immune cells. It plays an important role in blood circulation …

The progress of research focused on cholangiocytes and the biliary tree during development
and following injury is hindered by limited available quantitative methodologies. Current …

The Notch signaling pathway is evolutionarily conserved across metazoan species and
plays key roles in many physiological processes. The Notch receptor is activated by two …