The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the
cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …

Close proximities between organelles have been described for decades. However, only
recently a specific field dealing with organelle communication at membrane contact sites …

RNA transfer via extracellular vesicles (EVs) influences cell phenotypes; however, lack of
information regarding biogenesis of RNA-containing EVs has limited progress in the field …

The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …

Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …

Cellular organelles are not static but show dynamism—a property that is likely relevant for
their function. In addition, they interact with other organelles in a highly dynamic manner. In …

Organelles are physically connected by membrane contact sites. The endoplasmic reticulum
possesses three major receptors, VAP‐A, VAP‐B, and MOSPD2, which interact with proteins …

In eukaryotic cells, mitochondria are closely tethered to the endoplasmic reticulum (ER) at
sites called mitochondria‐associated ER membranes (MAMs). Ca2+ ion and phospholipid …

Abnormal function of suborganelles such as mitochondria and endoplasmic reticulum often
leads to abnormal function of cardiomyocytes or vascular endothelial cells and …

Viral replication is dependent on interactions between viral polypeptides and host proteins.
Identifying virus-host protein interactions can thus uncover unique opportunities for …