Triplication of genes encoded in human chromosome 21 (HSA21) is responsible for the
phenotypes of Down syndrome (DS). The dosage-imbalance of the nuclear genes and the …

Background Overexpression of the transsulfuration enzyme cystathionine-β-synthase (CBS),
and overproduction of its product, hydrogen sulfide (H 2 S) are recognized as potential …

The one‐carbon metabolism pathway is involved in critical human cellular functions such as
cell proliferation, mitochondrial respiration, and epigenetic regulation. In the homocysteine …

Objective Trisomy 21 is one of the most complex genetic perturbations compatible with
postnatal survival. Dosage imbalance arising from the triplication of genes on human …

Cellular redox state directs differentiation of induced pluripotent stem cells (iPSC) by energy
metabolism control and ROS generation. As oxidative stress and mitochondrial dysfunction …

Hydrogen sulfide (H2S) is a noxious, potentially poisonous, but necessary gas produced
from sulfur metabolism in humans. In Down Syndrome (DS), the production of H2S is …

The ubiquity of cognitive deficits and early onset Alzheimer's disease in Down syndrome
(DS) has focused much DS iPSC-based research on neuron degeneration and …

Introduction Down syndrome (DS) is the most common chromosomal disorder and it is
caused by trisomy of chromosome 21 (Hsa21). Subjects with DS show a large heterogeneity …

For many decades, neurons have been the central focus of studies on the mechanisms
underlying the neurodevelopmental and neurodegenerative aspects of Down syndrome …

Down syndrome (DS) is a genetic condition characterized by intellectual disability, delayed
brain development, and early onset Alzheimer's disease. The use of primary neural cells …