Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

PV Escribá, X Busquets, J Inokuchi, G Balogh… - Progress in lipid …, 2015 - Elsevier
Nowadays we understand cell membranes not as a simple double lipid layer but as a
collection of complex and dynamic protein–lipid structures and microdomains that serve as …

Membranes: a meeting point for lipids, proteins and therapies

PV Escribá, JM González‐Ros, FM Goñi… - Journal of cellular …, 2008 - Wiley Online Library
• Introduction• Membrane lipid composition• Membrane lipid structure• Membrane lipid
organization‐Why so many different lipids?‐Lipid mixing and demixing‐Lateral pressure …

Oleic acid content is responsible for the reduction in blood pressure induced by olive oil

S Teres, G Barceló-Coblijn, M Benet… - Proceedings of the …, 2008 - National Acad Sciences
Numerous studies have shown that high olive oil intake reduces blood pressure (BP). These
positive effects of olive oil have frequently been ascribed to its minor components, such as α …

Importance of the hexagonal lipid phase in biological membrane organization

J Jouhet - Frontiers in plant science, 2013 - frontiersin.org
Domains are present in every natural membrane. They are characterized by a distinctive
protein and/or lipid composition. Their size is highly variable from the nano-to the …

Omega‐3 PUFA profoundly affect neural, physiological, and behavioural competences–Implications for systemic changes in trophic interactions

M Pilecky, L Závorka, MT Arts, MJ Kainz - Biological Reviews, 2021 - Wiley Online Library
In recent decades, much conceptual thinking in trophic ecology has been guided by theories
of nutrient limitation and the flow of elements, such as carbon and nitrogen, within and …

Membrane-lipid therapy: a new approach in molecular medicine

PV Escribá - Trends in molecular medicine, 2006 - cell.com
Although most drugs bind to proteins and regulate their activity, some drugs act through a
new therapeutic approach called membrane-lipid therapy and bind to lipids, thus modulating …

The role of the lipid environment in the activity of G protein coupled receptors

R Baccouch, E Rascol, K Stoklosa, ID Alves - Biophysical chemistry, 2022 - Elsevier
G protein coupled receptors (GPCRs) are a class of membrane proteins that sense
extracellular signals ranging from light to odorants and small molecules and activate …

[HTML][HTML] Membrane composition and dynamics: a target of bioactive virgin olive oil constituents

S Lopez, B Bermudez, S Montserrat-De La Paz… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The endogenous synthesis of lipids, which requires suitable dietary raw materials, is critical
for the formation of membrane bilayers. In eukaryotic cells, phospholipids are the …

The significance of lipid composition for membrane activity: new concepts and ways of assessing function

L Vigh, PV Escribá, A Sonnleitner, M Sonnleitner… - Progress in lipid …, 2005 - Elsevier
In the last decade or so, it has been realised that membranes do not just have a lipid-bilayer
structure in which proteins are embedded or with which they associate. Structures are …

Drug-membrane interactions: significance for medicinal chemistry

M Lucio, J Lima, S Reis - Current medicinal chemistry, 2010 - ingentaconnect.com
Generally drugs can act on the level of different biological membranes as well as inside the
cells that are limited by membranes. Even in the latter situation, drugs must still interact with …