An autoimmune disease is defined as a clinical syndrome resulted from an instigation of
both T cell and B cell or individually, in the absence of any present infection or any sort of …

The human immune system involves highly complex and coordinated processes in which
small proteins named cytokines play a key role. Cytokines have been implicated in the …

Summary Background Upadacitinib, an oral Janus kinase (JAK) 1-selective inhibitor,
showed efficacy in combination with stable background conventional synthetic disease …

Objectives To compare efficacy and safety of sarilumab monotherapy with adalimumab
monotherapy in patients with active rheumatoid arthritis (RA) who should not continue …

Background Roughly a third of patients with rheumatoid arthritis treated with biological
treatments receive them as monotherapy. Tocilizumab—an inhibitor of interleukin 6 receptor …

Management and therapy of rheumatoid arthritis (RA) has been revolutionized by the
development and approval of the first biological disease-modifying antirheumatic drugs …

Objective In patients with active rheumatoid arthritis (RA) despite methotrexate, to compare
the efficacy of adding tocilizumab to that of switching to tocilizumab monotherapy. Methods …

Objectives. To assess the proportion of RA patients who discontinued biologics in world
registries and health care databases and to identify causes and predictors of …

Background and aims Medication persistence, defined as the time from drug initiation to
discontinuation of therapy, has been suggested as a proxy for real-world therapeutic benefit …

Over recent decades, treatment options for inflammatory diseases such as rheumatoid
arthritis (RA) have increased dramatically. These range from orally available steroids and …