Chronic hepatitis C virus (HCV) infection is associated with several extrahepatic
manifestations. Patients with HCV may develop mixed cryoglobulinemia and its sequelae …

Virus infections usually begin in peripheral tissues and can invade the mammalian nervous
system (NS), spreading into the peripheral (PNS) and more rarely the central (CNS) nervous …

Extrahepatic manifestations are a feature of chronic hepatitis C virus (HCV) infection. In the
course of chronic HCV infection, about 70% of patients have one or more extrahepatic …

The chronic dysfunction of neuronal cells, both central and peripheral, a characteristic of
neurological disorders, may be caused by irreversible damage and cell death. In 2016, more …

The blood–brain barrier (BBB) is formed by microvascular endothelial cells sealed by
tetraspanning tight junction (TJ) proteins, such as claudins and TAMPs (TJ-associated …

Background Reliable human in vitro blood–brain barrier (BBB) models suitable for high-
throughput screening are urgently needed in early drug discovery and development for …

As the primary protective barrier for neurons in the brain, the blood–brain barrier (BBB)
exists between the blood microcirculation system and the brain parenchyma. The normal …

Cerebral small vessel disease (SVD) gives rise to one in five strokes worldwide and
constitutes a major source of cognitive decline in the elderly. SVD is known to occur in …

Blood-brain barrier (BBB) dysfunction is a hallmark of neurological conditions such as
multiple sclerosis (MS) and stroke. However, the molecular mechanisms underlying …

Parkinsonism secondary to viral infections is not an uncommon occurrence and has been
brought under the spotlight with the spread of severe acute respiratory syndrome …