T follicular helper (TFH) cells are specialized effector CD4+ T cells critical to humoral
immunity. Whether post-transcriptional regulation has a function in TFH cells is unknown …

Viral infections present significant challenges to human health, underscoring the importance
of understanding the immune response for effective therapeutic strategies. Immune cell …

Long noncoding RNAs (lncRNAs) involved in the regulation of antiviral innate immune
responses need to be further identified. By functionally screening the lncRNAs in …

During an immune response to microbial infection, CD8+ T cells give rise to short-lived
effector cells and memory cells that provide sustained protection. Although the …

Genome-wide analyses in the last decade have uncovered the presence of a large number
of long non-protein-coding transcripts that show highly tissue-and state-specific expression …

Despite extensive mapping of long noncoding RNAs in immune cells, their function in vivo
remains poorly understood. In this study, we identify over 100 long noncoding RNAs that are …

Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor
CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers …

Invariant natural killer T (iNKT) cells are highly conserved innate-like T lymphocytes that
originate from CD4+ CD8+ double-positive (DP) thymocytes. Here, we report that …

Viral infection leads to large alterations in the host transcriptome and stimulates an antiviral
host immune response involving numerous proteins and signalling pathways. Long non …

The kinase PDK1 is a crucial regulator for immune cell development by connecting PI3K to
downstream AKT signaling. However, the roles of PDK1 in CD4+ T cell differentiation …