The TET family of proteins: functions and roles in disease

AY Tan, JL Manley - Journal of molecular cell biology, 2009 - academic.oup.com
Translocated in liposarcoma, Ewing's sarcoma and TATA-binding protein-associated factor
15 constitute an interesting and important family of proteins known as the TET proteins. The …

Polycation-π interactions are a driving force for molecular recognition by an intrinsically disordered oncoprotein family

J Song, SC Ng, P Tompa, KAW Lee… - PLoS computational …, 2013 - journals.plos.org
Molecular recognition by intrinsically disordered proteins (IDPs) commonly involves specific
localized contacts and target-induced disorder to order transitions. However, some IDPs …

Structure‐Function Based Molecular Relationships in Ewing's Sarcoma

R Todorova - BioMed research international, 2015 - Wiley Online Library
Ewing's Sarcoma Oncogene (ews) on chromosome 22q12 is encoding a ubiquitously
expressed RNA‐binding protein (EWS) with unknown function that is target of tumor‐specific …

Differential interaction of PRMT1 with RGG‐boxes of the FET family proteins EWS and TAF15

KKC Li, BL Chau, KAW Lee - Protein Science, 2018 - Wiley Online Library
The FET sub‐family (F US/T LS, E WS, T AF15) of RNA‐binding proteins have remarkably
similar overall structure but diverse biological and pathological roles. The molecular basis …

Molecular recognition by the EWS transcriptional activation domain

KAW Lee - Fuzziness: Structural Disorder in Protein Complexes, 2012 - Springer
Abstract Interactions between Intrinsically Disordered Protein Regions (IDRs) and their
targets commonly exhibit localised contacts via target-induced disorder to order transitions …

RGG boxes within the TET/FET family of RNA-binding proteins are functionally distinct

BL Chau, KP Ng, KKC Li, KAW Lee - Transcription, 2016 - Taylor & Francis
The multi-functional TET (TAF15/EWS/TLS) or FET (FUS/EWS/TLS) protein family of higher
organisms harbor a transcriptional-activation domain (EAD) and an RNA-binding domain …

A transcription assay for EWS oncoproteins in Xenopus oocytes

KP Ng, F Cheung, KAW Lee - Protein & cell, 2010 - Springer
Aberrant chromosomal fusion of the Ewing's sarcoma oncogene (EWS) to several different
cellular partners produces the Ewing's family of oncoproteins (EWS-fusion-proteins, EFPs) …

[引用][C] Polycation-p Interactions Are a Driving Force for Molecular Recognition by an Intrinsically Disordered

J Song, SC Ng, P Tompa, KAW Lee, HS Chan - 2013