The central cholinergic system includes the basal forebrain nuclei, mainly projecting to the
cortex, the mesopontine tegmental nuclei, mainly projecting to the thalamus and subcortical …

Cardinal motor symptoms in Parkinson's disease (PD) include bradykinesia, rest tremor
and/or rigidity. This symptomatology can additionally encompass abnormal gait, balance …

A rich and complex temporal structure of variability in postural sway characterizes healthy
and adaptable postural control. However, neurodegenerative disorders such as Parkinson's …

Background Gait disturbance is an early, disabling feature of Parkinson's disease (PD) that
is typically refractory to dopaminergic medication. The cortical cholinergic system …

Parkinson's disease (PD) is a systemic brain disorder where the cortical cholinergic network
begins to degenerate early in the disease process. Readily accessible, quantitative, and …

Dysfunction and degeneration of CNS cholinergic systems is a significant component of
multi-system pathology in Parkinson's disease (PD). We review the basic architecture of …

Free-water imaging can predict and monitor dopamine system degeneration in people with
Parkinson's disease. It can also enhance the sensitivity of traditional diffusion tensor imaging …

Gait and balance disorders are common signs in several neurodegenerative diseases such
as Parkinson's disease, atypical parkinsonism, idiopathic normal pressure hydrocephalus …

Background Dysfunction of cerebellar vermis contributes to gait abnormalities in multiple
conditions and may play a key role in gait impairment in Parkinson's disease (PD). Objective …

Background The contribution of cholinergic degeneration to gait disturbance in Parkinson's
disease (PD) is increasingly recognized, yet its relationship with dopaminergic-resistant gait …