This review is an updated and expanded version of the five prior reviews that were
published in this journal in 1997, 2003, 2007, 2012, and 2016. For all approved therapeutic …

An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Antibiotics that use novel mechanisms are needed to combat antimicrobial resistance,–.
Teixobactin represents a new class of antibiotics with a unique chemical scaffold and lack of …

Guanidines are fascinating small nitrogen-rich organic compounds, which have been
frequently associated with a wide range of biological activities. This is mainly due to their …

This review covers some of the recent progress in the field of peptide antibiotics with a focus
on compounds with novel or established mode of action and with demonstrated efficacy in …

The natural antibiotic teixobactin kills pathogenic bacteria without detectable resistance. The
difficult synthesis and unfavourable solubility of teixobactin require modifications, yet …

Covering: 2017–2019 Guanidine natural products isolated from microorganisms, marine
invertebrates and terrestrial plants, amphibians and spiders, represented by non-ribosomal …

Antimicrobial resistance is a serious threat to human health worldwide, prompting research
efforts on a massive scale in search of novel antibiotics to fill an urgent need for a remedy …

Metabolites with high chemical reactivity serve important roles in chemical defenses of
organisms. Formaldehyde, as a simple and highly reactive small molecule, can be produced …

The discovery of antibiotics has led to the effective treatment of bacterial infections that were
otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an …