Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments
The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …
related disorders remain unclear, but studies in depressed patients and rodent models are …
Role of BDNF in the pathophysiology and treatment of depression: Activity‐dependent effects distinguish rapid‐acting antidepressants
The pathophysiology and treatment of depression have been the focus of intense research
and while there is much that remains unknown, modern neurobiological approaches are …
and while there is much that remains unknown, modern neurobiological approaches are …
[HTML][HTML] Cortical GABAergic dysfunction in stress and depression: new insights for therapeutic interventions
Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
Biochemical mechanisms underlying psychedelic-induced neuroplasticity
DE Olson - Biochemistry, 2022 - ACS Publications
In addition to producing profound subjective effects following acute administration,
psychedelic compounds can induce beneficial behavioral changes relevant to the treatment …
psychedelic compounds can induce beneficial behavioral changes relevant to the treatment …
Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation
The rapidly acting antidepressants ketamine and scopolamine exert behavioral effects that
can last from several days to more than a week in some patients. The molecular …
can last from several days to more than a week in some patients. The molecular …
Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine
Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …
The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?
The discovery of the antidepressant effects of ketamine has opened a breakthrough
opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants …
opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants …
Cannabidiol induces rapid and sustained antidepressant-like effects through increased BDNF signaling and synaptogenesis in the prefrontal cortex
Currently available antidepressants have a substantial time lag to induce therapeutic
response and a relatively low efficacy. The development of drugs that addresses these …
response and a relatively low efficacy. The development of drugs that addresses these …
Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine
K Fukumoto, MV Fogaça, RJ Liu… - Proceedings of the …, 2019 - National Acad Sciences
Ketamine, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, produces
rapid and long-lasting antidepressant effects in major depressive disorder (MDD) patients.(2 …
rapid and long-lasting antidepressant effects in major depressive disorder (MDD) patients.(2 …
The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects
The ability of ketamine administration to activate prefrontal glutamate neurotransmission is
thought to be a key mechanism contributing to its transient psychotomimetic effects and its …
thought to be a key mechanism contributing to its transient psychotomimetic effects and its …