Chronic pain is associated with abnormal excitability of the somatosensory system and
remains poorly treated in the clinic. Potassium (K+) channels are crucial determinants of …

The intrinsic electrical characteristics of different types of neurons are shaped by the K+
channels they express. From among the more than 70 different K+ channel genes …

Scn2a encodes the voltage-gated sodium channel Na V 1.2, a main mediator of neuronal
action potential firing. The current paradigm suggests that Na V 1.2 gain-of-function variants …

Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral
nervous system and are crucial mediators of neuronal excitability. Importantly, these …

The axon initial segment (AIS) is positioned between the axonal and somato-dendritic
compartments and plays a pivotal role in triggering action potentials (APs) and determining …

Kv2 family “delayed-rectifier” potassium channels are widely expressed in mammalian
neurons. Kv2 channels activate relatively slowly and their contribution to action potential …

Many animals use the interaural time differences (ITDs) to locate the source of low frequency
sounds. The place coding theory proposed by Jeffress has long been a dominant model to …

Electrical excitation of peripheral somatosensory nerves is a first step in generation of most
pain signals in mammalian nervous system. Such excitation is controlled by an intricate set …

A workshop of the 2015 International Neuropathic Pain Congress was focused on potassium
channels to propose emerging ideas on the role of these channels on pain modulation and …

Little is known about the voltage-dependent potassium currents underlying spike
repolarization in midbrain dopaminergic neurons. Studying mouse substantia nigra pars …