Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell
death, and seed in secondary organs. An increased focus on cancer lipid metabolism has …

Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an
adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy …

With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Metabolic reprogramming contributes to tumor development and introduces metabolic
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …

Metabolism in immune cells is no longer thought of as merely a process for adenosine
triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of …