Disulfiram: mechanisms, applications, and challenges

J Lanz, N Biniaz-Harris, M Kuvaldina, S Jain, K Lewis… - Antibiotics, 2023 - mdpi.com
Background: Since disulfiram's discovery in the 1940s and its FDA approval for alcohol use
disorder, other indications have been investigated. This review describes potential clinical …

Old wine in new bottles: Advanced drug delivery systems for disulfiram-based cancer therapy

A McMahon, W Chen, F Li - Journal of Controlled Release, 2020 - Elsevier
Disulfiram (DSF) is an FDA-approved drug that has been repurposed for cancer treatment. It
showed excellent anticancer efficacy in combination with copper ions (Cu). Several active …

A polyurethane integrating self-healing, anti-aging and controlled degradation for durable and eco-friendly E-skin

F Li, Z Xu, H Hu, Z Kong, C Chen, Y Tian… - Chemical Engineering …, 2021 - Elsevier
Two of the very important demands for the elastic matrix of electronic skin (E-skin) are
durability and degradability, which ensure the stable performance in daily life and green end …

QSAR study of unsymmetrical aromatic disulfides as potent avian SARS-CoV main protease inhibitors using quantum chemical descriptors and statistical methods

S Chtita, A Belhassan, M Bakhouch, AI Taourati… - Chemometrics and …, 2021 - Elsevier
In silico research was executed on forty unsymmetrical aromatic disulfide derivatives as
inhibitors of the SARS Coronavirus (SARS-CoV-1). Density functional theory (DFT) …

Electrochemical synthesis of carbamo (dithioperoxo) thioates through the dehydrogenation coupling of thiols and amines and the insertion of CS 2

Q Wang, CH Xu, YC Wang, YM Pan, WG Duan… - Green …, 2022 - pubs.rsc.org
A convenient and practical strategy was developed for the synthesis of carbamo
(dithioperoxo) thioates through the simple dehydrogenation coupling of thiols and amines …

The revival of dithiocarbamates: from pesticides to innovative medical treatments

L Kaul, R Süss, A Zannettino, K Richter - IScience, 2021 - cell.com
Dithiocarbamates (DTCs) have been used for various applications, including as hardening
agents in rubber manufacturing, as fungicide in agriculture, and as medications to treat …

The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label use

KM Pfarr, AK Krome, I Al-Obaidi, H Batchelor… - Parasites & …, 2023 - Springer
In its 'Road map for neglected tropical diseases 2021–2030', the World Health Organization
outlined its targets for control and elimination of neglected tropical diseases (NTDs) and …

The combination of diethyldithiocarbamate and copper ions is active against Staphylococcus aureus and Staphylococcus epidermidis biofilms in vitro and in vivo

L Kaul, AI Abdo, T Coenye, BP Krom… - Frontiers in …, 2022 - frontiersin.org
Staphylococcus aureus and Staphylococcus epidermidis are associated with life-threatening
infections. Despite the best medical care, these infections frequently occur due to antibiotic …

Fabrication, characterization and in vitro evaluation of disulfiram-loaded cellulose acetate/poly (ethylene oxide) nanofiber scaffold for breast and colon cancer cell …

G El Fawal, MM Abu-Serie, H El-Gendi… - International Journal of …, 2022 - Elsevier
Cancer and microbial infections threaten human health. Currently, chemotherapeutic drugs
for cancer lack selectivity between normal and cancer cells, exacerbating this problem …

Gut microbiome: an intermediary to neurotoxicity

JL Dempsey, M Little, JY Cui - Neurotoxicology, 2019 - Elsevier
There is growing recognition that the gut microbiome is an important regulator for
neurological functions. This review provides a summary on the role of gut microbiota in …