Conformational penalties: New insights into nucleic acid recognition

A Geng, R Roy, HM Al-Hashimi - Current Opinion in Structural Biology, 2024 - Elsevier
Highlights•Conformational penalties to form alternative conformational states of nucleic
acids greatly contribute to nucleic acid-protein recognition.•Methods to determine nucleic …

Proteome-wide assessment of protein structural perturbations under high pressure

HM Moran, E Manriquez-Sandoval, P Sharma… - PRX Life, 2024 - APS
One of the planet's more understudied ecosystems is the deep biosphere, where organisms
can experience high hydrostatic pressures (30–110 MPa); yet, by current estimates, these …

Differential responses in the core, active site and peripheral regions of cytochrome c peroxidase to extreme pressure and temperature

RK Zawistowski, BR Crane - Journal of Molecular Biology, 2024 - Elsevier
In consideration of life in extreme environments, the effects of hydrostatic pressure on
proteins at the atomic level have drawn substantial interest. Large deviations of temperature …

The effect of hydrostatic pressure on lipid membrane lateral structure.

NLC McCarthy, CL Chan, MU GECM, Y Liao… - Methods in …, 2024 - europepmc.org
High pressure is both an environmental challenge to which deep sea biology has to adapt,
and a highly sensitive thermodynamic tool that can be used to trigger structural changes in …