Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update
JM Kyriakis, J Avruch - Physiological reviews, 2012 - journals.physiology.org
The mammalian stress-activated families of mitogen-activated protein kinases (MAPKs)
were first elucidated in 1994, and by 2001, substantial progress had been made in …
were first elucidated in 1994, and by 2001, substantial progress had been made in …
The JNK signal transduction pathway
CR Weston, RJ Davis - Current opinion in cell biology, 2007 - Elsevier
The c-Jun NH2-terminal kinases (JNKs) are an evolutionarily conserved sub-group of
mitogen-activated protein (MAP) kinases. Recent studies have improved our understanding …
mitogen-activated protein (MAP) kinases. Recent studies have improved our understanding …
[PDF][PDF] Mixed lineage kinase 3 mediates release of C‐X‐C motif ligand 10–bearing chemotactic extracellular vesicles from lipotoxic hepatocytes
SH Ibrahim, P Hirsova, K Tomita, SF Bronk… - …, 2016 - Wiley Online Library
Mixed lineage kinase 3 (MLK3) deficiency reduces macrophage‐associated inflammation in
a murine model of nonalcoholic steatohepatitis (NASH). However, the mechanistic links …
a murine model of nonalcoholic steatohepatitis (NASH). However, the mechanistic links …
Mitogen-activated protein kinase pathways in osteoblasts
MB Greenblatt, JH Shim… - Annual review of cell and …, 2013 - annualreviews.org
Mitogen-activated protein kinases (MAPKs) are ancient signal transducers well
characterized as mediators of inflammation and neoplastic transformation. Recent work has …
characterized as mediators of inflammation and neoplastic transformation. Recent work has …
Role of mitogen-activated protein kinase kinase kinases in signal integration
BD Cuevas, AN Abell, GL Johnson - Oncogene, 2007 - nature.com
Mitogen-activated protein kinases (MAPKs) are members of a dynamic protein kinase
network through which diverse stimuli regulate the spatio-temporal activities of complex …
network through which diverse stimuli regulate the spatio-temporal activities of complex …
Chemical genetic analysis of the time course of signal transduction by JNK
Exposure of primary murine embryonic fibroblasts to tumor necrosis factor (TNF) causes
biphasic activation of the c-Jun NH 2-terminal kinase (JNK) signaling pathway. The early …
biphasic activation of the c-Jun NH 2-terminal kinase (JNK) signaling pathway. The early …
[HTML][HTML] Reactive oxygen species in TNFα-induced signaling and cell death
TNFα is a pleotropic cytokine that initiates many downstream signaling pathways, including
NF-κB activation, MAP kinase activation and the induction of both apoptosis and necrosis …
NF-κB activation, MAP kinase activation and the induction of both apoptosis and necrosis …
Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity
S Win, TA Than, BHA Le, C García-Ruiz… - Journal of …, 2015 - Elsevier
Background & Aims Sustained c-Jun N-terminal kinase (JNK) activation by saturated fatty
acids plays a role in lipotoxicity and the pathogenesis of non-alcoholic steatohepatitis …
acids plays a role in lipotoxicity and the pathogenesis of non-alcoholic steatohepatitis …
TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway
The biological response to tumor necrosis factor (TNF) involves activation of MAP kinases.
Here we report a mechanism of MAP kinase activation by TNF that is mediated by the Rho …
Here we report a mechanism of MAP kinase activation by TNF that is mediated by the Rho …
Infectious diseases
Microglia, brain-resident innate immune cells, have been extensively studied in
neurodegenerative contexts like Alzheimer's disease. The Coronavirus disease 2019 …
neurodegenerative contexts like Alzheimer's disease. The Coronavirus disease 2019 …