[HTML][HTML] Antimalarial drug resistance: literature review and activities and findings of the ICEMR network
L Cui, S Mharakurwa, D Ndiaye… - The American journal …, 2015 - ncbi.nlm.nih.gov
Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …
PfCRT and its role in antimalarial drug resistance
Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT
The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts
to control and eliminate malaria. For decades, treatment of malaria has relied on …
to control and eliminate malaria. For decades, treatment of malaria has relied on …
Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19
Abstract Chloroquine (CQ) and Hydroxychloroquine (HCQ) have been commonly used for
the treatment and prevention of malaria, and the treatment of autoimmune diseases for …
the treatment and prevention of malaria, and the treatment of autoimmune diseases for …
[HTML][HTML] Drug-resistant malaria: molecular mechanisms and implications for public health
Resistance to antimalarial drugs has often threatened malaria elimination efforts and
historically has led to the short-term resurgence of malaria incidences and deaths. With …
historically has led to the short-term resurgence of malaria incidences and deaths. With …
Chloroquine transport via the malaria parasite's chloroquine resistance transporter
The emergence and spread of chloroquine-resistant Plasmodium falciparum malaria
parasites has been a disaster for world health. Resistance is conferred by mutations in the …
parasites has been a disaster for world health. Resistance is conferred by mutations in the …
Decreasing pfmdr1 Copy Number in Plasmodium falciparum Malaria Heightens Susceptibility to Mefloquine, Lumefantrine, Halofantrine, Quinine, and Artemisinin
ABS Sidhu, AC Uhlemann… - The Journal of …, 2006 - academic.oup.com
The global dissemination of drug-resistant Plasmodium falciparum is spurring intense efforts
to implement artemisinin (ART)–based combination therapies for malaria, including …
to implement artemisinin (ART)–based combination therapies for malaria, including …
Malaria chemotherapeutics part I: History of antimalarial drug development, currently used therapeutics, and drugs in clinical development
M Schlitzer - ChemMedChem: Chemistry Enabling Drug …, 2007 - Wiley Online Library
Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …
Drug‐resistant malaria− an insight
JE Hyde - The FEBS journal, 2007 - Wiley Online Library
Despite intensive research extending back to the 1930s, when the first synthetic antimalarial
drugs made their appearance, the repertoire of clinically licensed formulations remains very …
drugs made their appearance, the repertoire of clinically licensed formulations remains very …
In Vivo Selection of Plasmodium falciparum Parasites Carrying the Chloroquine-Susceptible pfcrt K76 Allele after Treatment with Artemether-Lumefantrine in Africa
C Sisowath, I Petersen, MI Veiga… - The Journal of …, 2009 - academic.oup.com
Background Artemether-lumefantrine (AL) is a major and highly effective artemisinin-based
combination therapy that is becoming increasingly important as a new first-line therapy …
combination therapy that is becoming increasingly important as a new first-line therapy …